HP1a promotes chromatin liquidity and drives spontaneous heterochromatin compartmentalization.

Lucy Brennan, Hyeong-Ku Kim, Serafin Colmenares, Tatum Ego, Je-Kyung Ryu, Gary Karpen

Abstract readPreprint

In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lucy BrennanDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.

Hyeong-Ku KimDepartment of Physics and Astronomy, Seoul National University, Seoul, South Korea.

Serafin ColmenaresDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.

Tatum EgoDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.

Je-Kyung RyuDepartment of Physics and Astronomy, Seoul National University, Seoul, South Korea.

Gary KarpenDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.

Funding

Interplay Between Nuclear Organization and FunctionR35GM139653 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KARPEN, GARY H · 2021 to 2025

$4.4M

NIGMS NIH HHS R35 GM139653

6 · The paper itself

Abstract

Compartmentalization of the nucleus into heterochromatin and euchromatin is highly conserved across eukaryotes. Constitutive heterochromatin (C-Het) constitutes a liquid-like condensate that packages the repetitive regions of the genome through the enrichment of histone modification H3K9me3 and recruitment of its cognate reader protein Heterochromatin Protein-1 (HP1a). The ability for well-ordered nucleosome arrays and HP1a to independently form biomolecular condensates suggests that the emergent material properties of C-Het compartments may contribute to its functions such as force-buffering, dosage-dependent gene silencing, and selective permeability. Using an

Identifiers

PMID39868136

DOI10.1101/2024.10.18.618981

PMCPMC11761810

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.