Evidence map›Paper›PMID 39868120›Full record

ArticlebioRxiv : the preprint server for biology2025

BDNF in Ventrolateral Orbitofrontal Cortex to Dorsolateral Striatum Circuit Moderates Alcohol Consumption and Gates Alcohol Habit.

Sowmya Gunasekaran, Jeffrey J Moffat, Joshua D Epstein, Khanhky Phamluong, Yann Ehinger, Dorit Ron

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sowmya GunasekaranAlcohol and Addiction Research Group, Department of Neurology, University of California San Francisco, USA, 94107.
Jeffrey J MoffatAlcohol and Addiction Research Group, Department of Neurology, University of California San Francisco, USA, 94107.
Joshua D EpsteinAlcohol and Addiction Research Group, Department of Neurology, University of California San Francisco, USA, 94107.
Khanhky PhamluongAlcohol and Addiction Research Group, Department of Neurology, University of California San Francisco, USA, 94107.
Yann EhingerAlcohol and Addiction Research Group, Department of Neurology, University of California San Francisco, USA, 94107.
Dorit RonAlcohol and Addiction Research Group, Department of Neurology, University of California San Francisco, USA, 94107.

Funding

BDNF and Alcohol AddictionR37AA016848 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RON, DORIT · 2013 to 2022
$3.7M
BDNF in the ventral hippocampus and the acute and chronic actions of alcoholR01AA031832 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DORIT RON · 2024 to 2026
$1.5M
NIAAA NIH HHS R01 AA031832NIAAA NIH HHS R37 AA016848
6 · The paper itself

Abstract

BDNF plays a crucial role in shaping the structure and function of neurons. BDNF signaling in the dorsolateral striatum (DLS) is part of an endogenous pathway that protects against the development of alcohol use disorder (AUD). Dysregulation of BDNF levels in the cortex or dysfunction of BDNF/TrkB signaling in the DLS results in the escalation of alcohol drinking and compulsive alcohol use. The major source of BDNF in the striatum is the prefrontal cortex. We identified a small ensemble of BDNF-positive neurons in the ventrolateral orbitofrontal cortex (vlOFC), a region involved in AUD, that extend axonal projections to the DLS. We speculated that BDNF in vlOFC-to-DLS circuit may play a role in limiting alcohol drinking and that heavy alcohol use disrupts this protective pathway. We found that

Identifiers

PMID39868120
PMCPMC11761066

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.