Evidence map›Paper›PMID 39868113›Full record

ArticlebioRxiv : the preprint server for biology2025

Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis.

Bo Sun, Dominique Fernandes, Anne-Kathrin Kienzler, Sofija Paneva, Ruby Harrison, Sudarshini Ramanathan, Anna L Harrison, Mateusz Makuch, Miriam L Fichtner, Robert F Donat and 32 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

42 authors.

Bo SunNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Dominique FernandesCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Anne-Kathrin KienzlerNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Sofija PanevaNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Ruby HarrisonNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Sudarshini RamanathanNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Anna L HarrisonNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Mateusz MakuchNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Miriam L FichtnerDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, 06511, USA.
Robert F DonatRadcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Deniz AkdenizNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Halwan BayuanggaNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Min Gyu ImNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Robyn WilliamsDepartments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Ana VasconcelosCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Selina ThomsenDepartments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Andrew FowerNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Ruyue SunNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Hannah FoxNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Victor MgbachiNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Alexander DaviesNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Mandy TsengNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Adam HandelNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Mark KellyNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Meng ZhaoNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
James BancroftCellular Imaging Core Facility, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, OX3 7BN, Oxford, United Kingdom.
Rachael Bashford-RogersDepartment of Biochemistry, Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN Oxford, UK.
John V PluvinageUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
Ravi DandekarUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
Bonny D AlvarengaUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
Lynn DustinKennedy Institute of Rheumatology, Roosevelt Drive, Headington, Oxford, OX3 7FY, United Kingdom.
Simon RinaldiNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Ray OwensDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Daniel AnthonyDepartment of Pharmacology, University of Oxford, United Kingdom.
David L BennettNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Patrick WatersNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.
Simon J DavisRadcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Michael R WilsonUCSF Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA.
Kevin C O'ConnorDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, 06511, USA.
John SoltysDepartments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Ana Luisa CarvalhoCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Sarosh R IraniNuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, Oxford, United Kingdom.ORCID 0000-0002-7667-9748

Funding

Autoimmune Encephalitis - Ataxia and Psychiatric Disease: Identifying and Characterizing Novel Antibody TargetsR01MH122471 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSEPH L. DERISI, SAMUEL JEREMY PLEASURE · 2020 to 2026
$4.7M
NIMH NIH HHS R01 MH122471Wellcome Trust
6 · The paper itself

Abstract

Autoimmunity affects 10% of the population. Within this umbrella, autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the developmental pathway of disease-causing B cells and autoantibodies. While such autoreactivities are believed to be generated during germinal centre reactions, the roles of earlier immune checkpoints in autoantigen-specific B cell tolerance are poorly understood. We address this concept in patients with CASPR2-autoantibody encephalitis and healthy controls. In both groups, comparable and high (~0.5%) frequencies of unmutated CASPR2-reactive naïve B cells were identified. By contrast, CASPR2-reactive memory B cells were exclusive to patients, and their B cell receptors demonstrated affinity-enhancing somatic mutations with heterogenous binding kinetics. These effector molecules possessed epitope-dependent pathogenic effects

Identifiers

PMID39868113
PMCPMC11760777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.