Evidence map›Paper›PMID 39868097›Full record

ArticlebioRxiv : the preprint server for biology2025

Enforced E-selectin ligand installation enhances homing and efficacy of adoptively transferred T cells.

Yingqin Hou, Jinfeng Ye, Ke Qin, Leigh-Ann Cui, Shereen Chung, Digantkumar Gopaldas Chapla, Wenjian Wang, Yujie Shi, Mingkuan Chen, Kelley W Moremen and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yingqin HouDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Jinfeng YeDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Ke QinDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Leigh-Ann CuiDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Shereen ChungDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Digantkumar Gopaldas ChaplaDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, United States.
Wenjian WangDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Yujie ShiDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Mingkuan ChenDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.
Kelley W MoremenDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, United States.
Robert SacksteinDepartment of Translational Medicine & Translational Glycobiology Institute, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, United States.
Peng WuDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, United States.

Funding

Chemoenzymatic glycan editing for deciphering biological functions of glycansR35GM139643 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI Peng Wu · 2021 to 2026
$4.7M
Analysis of E-selectin Ligands of Human Acute Leukemia Cells and their Biology in LeukemogenesisU01CA225730 · NCI · FLORIDA INTERNATIONAL UNIVERSITY · PI MITSIADES, CONSTANTINE S., SACKSTEIN, ROBERT · 2019 to 2023
$3.0M
NCI NIH HHS U01 CA225730NIGMS NIH HHS R35 GM139643
6 · The paper itself

Abstract

Adoptive T-cell transfer has revolutionized the treatment of hematological malignancies. However, this approach has had very limited success in treating solid tumors, largely due to inadequate infiltration of vascularly administered T cells at tumor sites. The shear-resistant interaction between endothelial E-selectin and its cognate ligand expressed on leukocytes, sialyl Lewis X (sLe

Identifiers

PMID39868097
PMCPMC11761414

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.