Evidence map›Paper›PMID 39868094›Full record

ArticlebioRxiv : the preprint server for biology2025

Recurrent oncogenic ZC3H18 mutations stabilize endogenous retroviral RNA.

Tanzina Tanu, Anna M Cox, Jennifer Karlow, Priyanka Sharma, Xueyang He, Constance Wu, Swathy Babu, Jared Brown, Kevin M Brown, Stephen J Chanock and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Tanzina TanuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Anna M CoxDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Jennifer KarlowDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Priyanka SharmaDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Xueyang HeUniversity of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Constance WuStem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, 02115, USA.
Swathy BabuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Jared BrownDepartment of Data Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Kevin M BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20850, USA.ORCID 0000-0002-8558-6711
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20850, USA.
David LiuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20850, USA.
Kathleen H BurnsDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Paul L BoutzUniversity of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Megan L InscoDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.ORCID 0000-0002-6078-6506

Funding

Genomics-based approaches to understanding mechanistic alterations of spliceosome function in disease statesR01GM141544 · NIGMS · UNIVERSITY OF ROCHESTER · PI BOUTZ, PAUL LAWRENCE · 2021 to 2025
$1.6M
Investigating Transcriptional Elongation and Nuclear RNA Surveillance in MelanomaK08CA248727 · NCI · DANA-FARBER CANCER INST · PI INSCO, MEGAN LEIGH · 2021 to 2025
$980k
NCI NIH HHS K08 CA248727NIGMS NIH HHS R01 GM141544
6 · The paper itself

Abstract

Endogenous retroviral (ERV) RNA is highly expressed in cancer, although the molecular causes and consequences remain unknown. We found that ZC3H18 (Z18), a component of multiple nuclear RNA surveillance complexes, has recurrent truncating mutations in cancer. We show that Z18

Identifiers

PMID39868094
PMCPMC11760258

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.