ArticleiScience2025
Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Precision phage therapy in the AI/ML era: a systematic review of discovery-to-clinical translation evidence.Frontiers in microbiology · 2026Pooled it
- Phylogeny-agnostic strain-level prediction of phage-host interactions from genomes using machine learning.Nature microbiology · 2026Article
- Artificial Intelligence in Bacteriophage Science: A Comprehensive Narrative Review of Applications, Challenges, and Translational Opportunities.Antibiotics (Basel, Switzerland) · 2026Review
- Towards accurate artificial intelligence models for strain-level phage-host prediction.Briefings in bioinformatics · 2026Article
- Knowledge graph embedding for predicting and analyzing microbial interactions.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophages (phages) are increasingly viewed as a promising alternative for the treatment of antibiotic-resistant bacterial infections. However, the diversity of host ranges complicates the identification of target phages. Existing computational tools often fail to accurately identify phages across different bacterial species. In this study, we present GE-PHI, a machine-learning-based model for predicting phage-host interactions (PHIs) by integrating knowledge graph embedding algorithm with a large-scale protein language model. First, a phage-host heterogeneous association network (PHAN) was constructed that incorporated phage-phage and host-host similarity networks. Then, the multi-relational Poincaré graph embedding (MuRP) was used to extract topological patterns. Additionally, we employed the ESM-2 protein language model to capture evolutionary information from phage tail proteins and host-receptor-binding proteins. GE-PHI achieved a cross-validation area under the curve (AUC) of up to 0.9453 in silico and maintains this performance in case studies. This study provides insights into machine-learning-guided phage therapeutics and diagnostics in microbial engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.