Evidence map›Paper›PMID 39867885›Full record

ArticleFrontiers in immunology2024

Identification of hub genes and immune-related pathways in acute myeloid leukemia: insights from bioinformatics and experimental validation.

Mingliang Shan, Li Xu, Wenzhe Yang, Shiguo Liu, Zhaoqing Cui

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mingliang ShanPostdoctoral Workstation, Liaocheng People's Hospital, Liaocheng, China.
Li XuCollege of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, China.
Wenzhe YangPost - Doctoral Innovation Practice Base, Gaomi Maternity and Child Health Hospital, Gaomi, China.
Shiguo LiuPostdoctoral Mobile Stations, The Affiliated Hospital of Qingdao University, Qingdao, China.
Zhaoqing CuiPostdoctoral Workstation, Liaocheng People's Hospital, Liaocheng, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aims to identify the hub genes and immune-related pathways in acute myeloid leukemia (AML) to provide new theories for immunotherapy. Methods: We use bioinformatics methods to find and verify the hub gene. At the same time, we use the results of GSEA enrichment analysis to find immune-related mediators. Through Mendelian randomization(MR) analysis, on the one hand, we look for related immune cells, and on the other hand, we use it to determine the causal relationship among immune cells, immune mediators, and AML. Finally, Results: Complement Factor D( Conclusion: We conclude that

Indexed as

Computational BiologyLeukemia, Myeloid, AcuteGene Regulatory NetworksHumansInterleukin-2Signal TransductionInterleukin-2AMLbioinformaticshub genemachine learningMendelian randomizationplasmidRT-qPCR

Identifiers

PMID39867885
PMCPMC11757261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.