Evidence map›Paper›PMID 39867870›Full record

ArticleJournal of cellular immunology2024

Evaluation of Neutrophil Elastase Inhibitors as Potential Therapies for

Vahagn Makaryan, Merideth Kelley, Audrey Anna Bolyard, Gobind Chugh, David C Dale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. ModelingJournal of cellular immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vahagn MakaryanDepartment of Medicine, University of Washington, Seattle, Washington, U.S.A.
Merideth KelleyDepartment of Medicine, University of Washington, Seattle, Washington, U.S.A.
Audrey Anna BolyardDepartment of Medicine, University of Washington, Seattle, Washington, U.S.A.
Gobind ChughDepartment of Medicine, University of Washington, Seattle, Washington, U.S.A.
David C DaleDepartment of Medicine, University of Washington, Seattle, Washington, U.S.A.

Funding

Severe Chronic Neutropenia International RegistryR24AI049393 · NIAID · UNIVERSITY OF WASHINGTON · PI DALE, DAVID CHANDLER · 2004 to 2019
$10.6M
Severe Chronic Neutropenia International RegistryR24AI162637 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PETER E NEWBURGER, Akiko Shimamura · 2022 to 2026
$5.8M
Gene Editing vs Neutrophil Elastase Inhibitors for Treatment of ELANE Associated NeutropeniaR01HL151629 · NHLBI · UNIVERSITY OF WASHINGTON · PI DALE, DAVID CHANDLER · 2020 to 2022
$1.8M
NHLBI NIH HHS R01 HL151629NIAID NIH HHS R24 AI049393NIAID NIH HHS R24 AI162637
6 · The paper itself

Abstract

Neutrophil elastase (

Indexed as

Congenital neutropeniaCyclic neutropeniaELANEMK0339NeutropeniaNeutropenia therapyNeutrophil elastase

Identifiers

PMID39867870
PMCPMC11759478

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.