Evidence map›Paper›PMID 39867869›Full record

ArticleJournal of experimental pharmacology2025

Two Novel Compounds Isolated from the Marine Fungal Symbiont of

Muhammad Hasan Bashari, Mochamad Untung Kurnia Agung, Eko Fuji Ariyanto, Laode Muhammad Ramadhan Al Muqarrabun, Syefira Salsabila, Agus Chahyadi, Andi Rifki Rosandy, Ervi Afifah, Merry Afni, Harold Eka Atmaja and 6 more

Abstract read
In one paragraph

Article in Journal of experimental pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Muhammad Hasan BashariDepartment of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.ORCID 0000-0001-7298-0317
Mochamad Untung Kurnia AgungDepartment of Marine Science, Faculty of Fisheries and Marine Science, Universitas Padjadjaran, Bandung, West Java, Indonesia.ORCID 0000-0001-7844-9949
Eko Fuji AriyantoDepartment of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.ORCID 0000-0001-5161-4780
Laode Muhammad Ramadhan Al MuqarrabunUniversity Center of Excellence for Nutraceuticals, Bioscience and Biotechnology Research Center, Bandung Institute of Technology, Bandung, West Java, Indonesia.ORCID 0000-0003-3121-4995
Syefira SalsabilaUniversity Center of Excellence for Nutraceuticals, Bioscience and Biotechnology Research Center, Bandung Institute of Technology, Bandung, West Java, Indonesia.ORCID 0000-0002-3456-1864
Agus ChahyadiUniversity Center of Excellence for Nutraceuticals, Bioscience and Biotechnology Research Center, Bandung Institute of Technology, Bandung, West Java, Indonesia.ORCID 0000-0002-3625-4577
Andi Rifki RosandyUniversity Center of Excellence for Nutraceuticals, Bioscience and Biotechnology Research Center, Bandung Institute of Technology, Bandung, West Java, Indonesia.ORCID 0000-0003-1719-1993
Ervi AfifahGraduate School of Master Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.ORCID 0000-0003-4205-2434
Merry AfniBiomedical Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.ORCID 0000-0001-7522-1623
Harold Eka AtmajaBiomedical Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.ORCID 0000-0001-9062-4017
Tenny PutriBiomedical Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.ORCID 0000-0001-5313-9522
Fitria UtamiBiomedical Laboratory, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.ORCID 0000-0002-7609-9081
Beginer SubhanDepartment of Marine Science and Technology, Faculty of Fisheries and Marine Science, IPB University, Bogor, West Java, Indonesia.ORCID 0000-0002-2179-0721
SyafrizayantiBiochemistry Laboratory, Department of Chemistry, Universitas Andalas, Padang, West Sumatera, Indonesia.ORCID 0000-0002-4896-2722
Yosie AndrianiInstitute of Climate Adaptation and Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, Malaysia.ORCID 0000-0001-6854-6446
ElfahmiUniversity Center of Excellence for Nutraceuticals, Bioscience and Biotechnology Research Center, Bandung Institute of Technology, Bandung, West Java, Indonesia.ORCID 0000-0003-3586-5082

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: A promising feature of marine sponges is the potential anticancer efficacy of their secondary metabolites. The objective of this study was to explore the anticancer activities of compounds from the fungal symbiont of Methods: In the present research, Results: The extract showed cytotoxic activity in breast cancer cells. Two novel compounds were successfully isolated and identified, ie, Unguisol A (15.1 mg) and Unguisol B (97.9 mg). Both compounds share the same basic skeleton and comprise an aromatic ring which is attached to a sulphur-containing, seven-membered ring via an oxygen atom. This marked the first-time isolation of Unguisol A and Unguisol B from Conclusion: Two novel compounds were isolated from

Indexed as

Aspergillus unguisdrug screening assaysPoriferatriple negative breast neoplasms

Identifiers

PMID39867869
PMCPMC11766706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.