ArticleNature reviews. Physics2020
Measuring mechanical stress in living tissues.
Article in Nature reviews. Physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Sensing forces that shape tumours.Nature nanotechnology · 2026Article
- Multi-phase field model reveals internal dissipation is crucial for spontaneous hole formation in cell monolayers.Nature communications · 2026Article
- Protocol for inferring mechanical stresses in tissues using ForSys, an open-source Python tool.STAR protocols · 2026Article
- Using tunable hydrogel microparticles to measure cellular forces.Nature protocols · 2026Review
- Harmonic fields and the mechanical response of a cellular monolayer to ablation.Journal of mathematical biology · 2026Article
- Guidance for 3D traction force microscopy today and in the next decade.Nature methods · 2026Review
- Stabilized real-time Brillouin microscopy reveals fractal organization of protein condensates in living cells.Nature communications · 2026Article
- Mapping Collective Forces of Lung Cancer Spheroids Using Traction Force Microscopy.Biotechnology and bioengineering · 2026Article
- Construction and simulation-experimental characterization of a fluorescence image-based finite element model for cell mechanics.Frontiers in bioengineering and biotechnology · 2026Article
- Cellular mechanical properties in response to environmental viscosity imaged by Brillouin Microscopy.Communications biology · 2025Article
- Characterisation of cuticle mechanical properties: analysing stiffness in layered living systems to understand surface buckling patterns.Soft matter · 2025Article
- RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Application and measurement of tissue-scale tension in avian epithelia in vivo to study multiscale mechanics and inter-germ layer coupling.Development (Cambridge, England) · 2025Article
- A proposal for epithelial dominance in extremely high fundamental frequency vocalizations.The Journal of the Acoustical Society of America · 2025Article
- Uncertainty-aware traction force microscopy.PLoS computational biology · 2025Article
- Mechanical Behavior and Indentation-Induced Injury of Soft Microtissues with Different Densification Levels.ACS omega · 2025Article
- A computational pipeline for spatial mechano-transcriptomics.Nature methods · 2025Article
- Metareview: a survey of active matter reviews.The European physical journal. E, Soft matter · 2025Review
- The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025Review
- Deciphering the interplay between biology and physics with a finite element method-implemented vertex organoid model: A tool for the mechanical analysis of cell behavior on a spherical organoid shell.PLoS computational biology · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living tissues are active multifunctional materials capable of generating, sensing, withstanding and responding to mechanical stress. These capabilities enable tissues to adopt complex shapes during development, to sustain those shapes during homeostasis, and to restore them during healing and regeneration. Abnormal stress is associated with a broad range of pathologies, including developmental defects, inflammatory diseases, tumor growth and metastasis. Here we review techniques that measure mechanical stress in living tissues with cellular and subcellular resolution. We begin with 2D techniques to map stress in cultured cell monolayers, which provide the highest resolution and accessibility. These techniques include 2D traction microscopy, micro-pillar arrays, monolayer stress microscopy, and monolayer stretching between flexible cantilevers. We next focus on 3D traction microscopy and the micro-bulge test, which enable mapping forces in tissues cultured in 3D. Finally, we review techniques to measure stress
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.