ArticleInternational journal of cardiology. Cardiovascular risk and prevention2025
Inflammatory bowel disease is associated with an increased risk of cardiovascular events in a sex and age-dependent manner: A historical cohort study.
Article in International journal of cardiology. Cardiovascular risk and prevention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Beyond Inflammation - A Multidisciplinary Approach to Managing Obesity and Cardiometabolic Risk in Inflammatory Bowel Disease.Current diabetes reports · 2026Review
- Cardiovascular Complications Are Increased in Inflammatory Bowel Disease: A Path Toward Achievement of a Personalized Risk Estimation.Journal of personalized medicine · 2025Article
- Management of Atherosclerotic Cardiovascular Risk in Inflammatory Bowel Disease: Current Perspectives.Advances in therapy · 2025Review
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Authors and funding
2 authors.
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Abstract
Background: The relationship between inflammatory bowel diseases (IBD) and the risk of ischemic heart diseases (IHD) remains a subject of debate. In this study, we sought to investigate the association between IBD and long-term risk of IHD in a substantial cohort of IBD patients. Methods: In this retrospective cohort study we utilized data from a state-mandated provider in Israel (Maccabi Healthcare Services). We identified all eligible patients diagnosed with IBD between 1/1990 and 7/2021 that were individually matched by sex-and-birth date to 10 MHS members with no indication of IBD. Study population was followed through the data until 12/2021 to examine the occurrence of IHD events. Results: A total of 14,768 IBD patients (6144 UC, 8624 CD) and 120338 matched non-IBD individuals were eligible for the analysis. Over a mean follow-up of 10.5 years, 285 (1.9 %) of participants with IBD and 1175 (1.0 %) of the reference group experienced our composite outcome, representing an HR of 1.98 (95%CI: 1.74-2.25). When stratified by sex, risk of IHD associated with IBD in males (HR = 1.82; 95 % CI: 1.52-2.17), whereas a negative association was noted among female patients (HR = 0.72; 95%CI: 0.55-0.95). Study results were generally unchanged when analyses were limited to patients with CD, UC, patients on steroids, and patients on immunosuppressants. Conclusions: Our study reveals a notable excess risk of IHD in male patients with IBD. Further research is needed to better elucidate the mechanisms involved in this relationship.
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