Evidence map›Paper›PMID 39867743›Full record

ReviewTherapeutic advances in medical oncology2025

Rare epithelial gastric cancers: a review of the current treatment knowledge.

Angelica Petrillo, Margaret Ottaviano, Luca Pompella, Emilio Francesco Giunta, Pasquale Pisapia, Gianpaolo Marte, Andrea Tufo, Sara Di Lorenzo, Jessica Orefice, Chiara Miceli and 3 more

Abstract readReview
In one paragraph

Review in Therapeutic advances in medical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Angelica PetrilloMedical Oncology Unit, Ospedale del Mare, Via E. Russo, Naples 80147, Italy.ORCID https://orcid.org/0000-0001-5489-5733
Margaret OttavianoDepartment of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.
Luca PompellaMedical Oncology Unit, Ospedale Ave Gratia Plena, ASL Caserta, San Felice a Cancello, Italy.
Emilio Francesco GiuntaDepartment of Experimental Medicine, Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy.ORCID https://orcid.org/0000-0002-5383-4469
Pasquale PisapiaDepartment of Public Health, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0002-6429-0620
Gianpaolo MarteSurgical Unit, Ospedale del Mare, Naples, Italy.
Andrea TufoSurgical Unit, Ospedale del Mare, Naples, Italy.
Sara Di LorenzoDepartment of Precision Medicine, Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy.
Jessica OreficeDepartment of Precision Medicine, Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy.
Chiara MiceliDepartment of Precision Medicine, Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy.
Umberto MalapelleDepartment of Public Health, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0003-3211-9957
Bruno DanieleMedical Oncology Unit, Ospedale del Mare, Naples, Italy.
Ferdinando De VitaDepartment of Precision Medicine, Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC), one of the tumours with the highest mortality worldwide, is not a homogeneous disease, showing different features according to location, macroscopic aspect, histotype and molecular alterations. Adenocarcinoma is the most frequent epithelial GC (95%), the remaining 5% comprising rare epithelial tumours with their peculiarities, behaviour and incidence <6 cases/100,000/year. Due to the low number of cases, many aspects must be elucidated in this context. In this narrative review, we highlight the importance of a better understanding of rare GCs to personalize the cures in the light of the precision medicine concept. Our main aim is to translate the scarce evidence from the literature into daily clinical practice, never forgetting that all the clinicians dedicated to rare GCs should encourage such patients' enrolment in clinical trials and promote international collaborations. Hence, we focused on the treatment of the following rare GCs: rare gastric adenocarcinomas (hepatoid adenocarcinoma, medullary carcinoma with lymphoid stroma, Paneth cell carcinoma and Salivary Gland carcinoma); squamous cell carcinoma; adenosquamous carcinoma; neuroendocrine gastric neoplasms; gastroblastoma.

Indexed as

adenosquamous carcinomaEpstein–Barr virusgastroblastomaGEP-NENhepatoid adenocarcinomamicrosatellite instabilityneuroendocrine gastric tumoursPaneth cell carcinoma and the Salivary Gland carcinomarare gastric adenocarcinomassquamous cell carcinomathe medullary carcinoma with lymphoid stroma

Identifiers

PMID39867743
PMCPMC11760139

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.