ArticleFrontiers in pediatrics2024
Relationship between pregnant women's combined exposure to heavy metals and their offspring's congenital heart defects in Lanzhou, China.
Article in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The Impact of Arsenic, Cadmium, Lead, Mercury, and Thallium Exposure on the Cardiovascular System and Oxidative Mechanisms in Children.Current issues in molecular biology · 2025Review
- Spatial Epidemiologic Analysis of Fetal Birth Defects in Guangxi, China.International journal of general medicine · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
Background: Previous research has demonstrated that exposure to individual heavy metals elevates the incidence rate of congenital heart defects (CHDs). However, there is a paucity of data concerning the relationship between combined exposure to multiple heavy metals and the occurrence of CHDs. This study seeks to investigate the association between combined heavy metal exposure in pregnant women and the incidence of CHDs in their offspring in Lanzhou, China. Methods: We conducted a comprehensive review of the birth cohort study undertaken at our hospital from 2010 to 2012, with the objective of investigating the association between combined heavy metal exposure in pregnant women and the incidence of CHDs in their offspring. This analysis was performed utilizing a multifactorial conditional logistic regression model. Result: A nested case-control study was conducted involving 97 case groups and 194 control groups. The median concentrations of nickel (Ni), barium (Ba), lead (Pb), and titanium (Ti) in the blood of pregnant women were measured at 25.58 μg/L, 84.38 μg/L, 69.67 μg/L, and 304.65 μg/L, respectively. The research identified a significant correlation between the concentrations of Ni, Pb, and Ti in the blood of pregnant women and the risk of CHDs ( Conclusion: The cumulative exposure levels of Ni, Ba, Pb, and Ti in the blood of pregnant women are correlated with an elevated risk of CHDs in their offspring.
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