Evidence map›Paper›PMID 39867572›Full record

ArticleAcademia oncology2024

Circulating tumor DNA in head and neck squamous cell carcinoma-current status and future prospects.

Samuel Auger, Vasudha Mishra, Alka Singh, Yuxuan Miao, Nishant Agrawal, Evgeny Izumchenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Academia oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samuel AugerSection of Otolaryngology-Head and Neck Surgery, University of Chicago, Chicago, IL 60637, USA.
Vasudha MishraDepartment of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL 60637, USA.
Alka SinghDepartment of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL 60637, USA.
Yuxuan MiaoBen May Department of Cancer Research, The University of Chicago, Chicago, IL 60637, USA.
Nishant AgrawalSection of Otolaryngology-Head and Neck Surgery, University of Chicago, Chicago, IL 60637, USA.
Evgeny IzumchenkoDepartment of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL 60637, USA.

Funding

Multi-analyte Approach for Earlier Detection of Cancers in Non Plasma BiofluidsU01CA230691 · NCI · JOHNS HOPKINS UNIVERSITY · PI Nishant Agrawal, CHETAN BETTEGOWDA · 2018 to 2026
$6.7M
Delineating chromatin-related gene expression signatures as a function of HNSCC progressionR01DE027809 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI GAYKALOVA, DARIA A, IZUMCHENKO, EVGENY (EUGENE) G · 2019 to 2023
$2.6M
Somatic Mutations in Tissue and Saliva as Prognostic and Screening Biomarkers for Oral PremalignancyR01DE028674 · NIDCR · UNIVERSITY OF CHICAGO · PI AGRAWAL, NISHANT, LINGEN, MARK W. · 2020 to 2024
$1.9M
NCI NIH HHS U01 CA230691NIDCR NIH HHS R01 DE027809NIDCR NIH HHS R01 DE028674
6 · The paper itself

Abstract

Squamous cell carcinoma (SCC) is the most common malignancy of the head and neck. Stagnating survival rates in recent decades, despite advances in the treatment paradigms, surveillance technologies, and multidisciplinary care, leave clinicians with a need for better options for screening, risk-stratifying, and monitoring patients. A growing proportion of patients with HPV-associated SCC have improved outcomes but continue to have a heterogenous response to treatment. Advances in the platforms and assays measuring circulating tumor DNA offer an opportunity to monitor disease status at the molecular level for both virally mediated and traditional risk-factor-driven SCC of the head and neck. This overview will discuss experimental, clinically used, and commercially available liquid biopsy platforms and their recent applications in patients with head and neck SCC malignancies.

Indexed as

circulating tumor DNAhead and neck cancerliquid biopsy

Identifiers

PMID39867572
PMCPMC11760339

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.