ArticleFrontiers in nutrition2024
Valine metabolite, 3-hydroxyisobutyrate, promotes lipid metabolism and cell proliferation in porcine mammary gland epithelial cells.
Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- The hallmarks of protein and amino acid restriction in aging and longevity.Cell press blue · 2026Article
- Integrating omics and functional data via representation learning to prioritize candidate genes for pleiotropic effect in dairy sheep.PNAS nexus · 2025Article
- Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice.bioRxiv : the preprint server for biology · 2025Article
- Identification of prognostic and therapeutic biomarkers associated with macrophage and lipid metabolism in pancreatic cancer.Scientific reports · 2025Article
- Gestational Inulin Supplementation in Low-/High-Fat Sow Diets: Effects on Growth Performance, Lipid Metabolism, and Meat Quality of Offspring Pigs.Foods (Basel, Switzerland) · 2025Article
- Effects of unconventional diets and unconventional low-protein diets on reproductive performance, placental nutrient transport, and fecal microorganisms of multiparous sows during gestation.Journal of animal science · 2025Article
- Genetically instrumented circulating metabolites and hepatobiliary cancer risk: A multi-tiered Mendelian randomization and functional interrogation.Frontiers in oncology · 2025Article
- Reduction in within-litter variation of piglet birth weight through dietary supplementation of 3-hydroxyisobutyric acid in sows.Frontiers in veterinary science · 2025Article
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11 authors.
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Abstract
Improving mammary gland epithelial cells proliferation through nutrition is an important approach for enhancing sow milk production and piglet growth. An intermediate metabolite of valine, 3-hydroxyisobutyrate (3-HIB), regulates cellular lipid metabolism. In the present study, we investigated the effects of 3-HIB on porcine mammary gland epithelial cells proliferation and lipid metabolism. The addition of an appropriate concentration of 3-HIB significantly increased mammary gland epithelial cell proliferation and the expression of proteins associated with cell proliferation. Compared to the control group, the addition of 0.4-0.8 mM 3-HIB increased the expression levels of mTOR signaling pathway-related proteins and the cell cycle protein, Cyclin D1, while inhibiting the expression of the cell cycle arrest protein, P27. The addition of 0.8 mM 3-HIB increased the triglyceride and lipid droplet content in the cells. The addition of 3-HIB increased the expression of proteins related to
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