Evidence map›Paper›PMID 39867440›Full record

ArticleACS physical chemistry Au2025

Structure Characterization of a Disordered Peptide Using In-Droplet Hydrogen/Deuterium Exchange Mass Spectrometry and Molecular Dynamics.

Mohammad A Rahman, Mst Nigar Sultana, Daud Sharif, Sultan Mahmud, Justin Legleiter, Peng Li, Blake Mertz, Stephen J Valentine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS physical chemistry Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad A RahmanDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.
Mst Nigar SultanaDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.
Daud SharifDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.
Sultan MahmudDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.
Justin LegleiterDepartment of Biochemistry & Molecular Biology, University of Nevada, Reno, Reno, Nevada 89557, United States.ORCID https://orcid.org/0000-0002-5262-1867
Peng LiDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0000-0002-8332-7142
Blake MertzAlivexis, Cambridge, Massachusetts 02142, United States.
Stephen J ValentineDepartment of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States.ORCID https://orcid.org/0000-0003-4360-2928

Funding

Development of VSSI-probe technology for in situ probing biological systems using mass spectrometryR01GM135432 · NIGMS · WEST VIRGINIA UNIVERSITY · PI LI, PENG · 2019 to 2023
$1.7M
NIGMS NIH HHS R01 GM135432
6 · The paper itself

Abstract

In-droplet hydrogen/deuterium exchange (HDX)-mass spectrometry (MS) experiments have been conducted for peptides of highly varied conformational type. A new model is presented that combines the use of protection factors (PF) from molecular dynamics (MD) simulations with intrinsic HDX rates (

Identifiers

PMID39867440
PMCPMC11758492

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.