Evidence map›Paper›PMID 39867392›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Tau Burden is Best Captured by Magnitude and Extent: Tau-MaX as a Measure of Global Tau.

Christopher A Brown, Sandhitsu R Das, Katheryn A Q Cousins, Thomas F Tropea, Alice-Chen Plotkin, John A Detre, Paul A Yushkevich, Corey T McMillan, Edward B Lee, Leslie M Shaw and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Christopher A BrownDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Sandhitsu R DasDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Katheryn A Q CousinsDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA, 19104.ORCID 0000-0003-1879-2766
Thomas F TropeaDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA, 19104.ORCID 0000-0003-0766-1496
Alice-Chen PlotkinDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA, 19104.
John A DetreDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Paul A YushkevichDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA, 19104.ORCID 0000-0001-8543-4016
Corey T McMillanDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA, 19104.ORCID 0000-0002-7581-6405
Edward B LeeDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Leslie M ShawDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Ilya M NasrallahDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA, 19104.
Alzheimer’s Disease Neuroimaging Initiative
David A WolkDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA, 19104.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI RICHARD Justin PERRIN · 2016 to 2026
$226.7M
Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Corey T McMillan · 2021 to 2026
$24.8M
Project IV: In Vivo Dissection of Genetic Modifiers on Different Stages of SynucleinopathyP01AG084497 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN · 2024 to 2026
$15.2M
Ex Vivo Imaging of the Aging Brain to Discover Morphology/Pathology AssociationsR01AG056014 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Paul A. Yushkevich · 2017 to 2026
$4.5M
Characterization of relationship between tau pathology and neurodegeneration in Alzheimer's disease using multimodal imagingR01AG072796 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Sandhitsu Das, DAVID A WOLK · 2022 to 2026
$4.0M
Modulators of Medial Temporal Lobe Subregion Structure and Function in Normal and Pathological AgingR01AG055005 · NIA · UNIVERSITY OF PENNSYLVANIA · PI WOLK, DAVID A · 2017 to 2021
$3.3M
Research Training Program in Disease Oriented Neuroscience (R25)R25NS065745 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 2009 to 2023
$3.0M
Improving the sensitivity and specificity of MRI-based biomarkers in Alzheimer's diseaseRF1AG069474 · NIA · UNIVERSITY OF PENNSYLVANIA · PI WOLK, DAVID A, YUSHKEVICH, PAUL A. · 2021 to 2021
$2.1M
Ex Vivo Imaging of the Aging Brain to Discover Morphology/Pathology AssociationsRF1AG056014 · NIA · UNIVERSITY OF PENNSYLVANIA · PI YUSHKEVICH, PAUL A. · 2023 to 2023
$2.1M
Improving the sensitivity and specificity of MRI-based biomarkers in Alzheimer's diseaseR01AG069474 · NIA · UNIVERSITY OF PENNSYLVANIA · PI WOLK, DAVID A, YUSHKEVICH, PAUL A. · 2024 to 2025
$1.4M
NIA NIH HHS P01 AG084497NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG055005NIA NIH HHS R01 AG056014NIA NIH HHS R01 AG069474NIA NIH HHS R01 AG072796NIA NIH HHS RF1 AG056014NIA NIH HHS RF1 AG069474NIA NIH HHS U19 AG024904NINDS NIH HHS R25 NS065745
6 · The paper itself

Abstract

Tau exhibits change in both spatial extent and density of pathology along the Alzheimer's disease (AD) spectrum with each aspect contributing to the overall burden of pathological tau. Nevertheless, studies using Tau PET have measured either magnitude using standardized uptake value ratios (SUVRs) or extent using number of Tau+ regions. We hypothesized that combining these two dimensions into a single measure of Magnitude and eXtent, Tau-MaX, would provide improved quantification of global tau burden as well as allowing for a region-agnostic measure of global tau burden that does not require a pre-specified region of interest (ROI) or meta-ROI. To test this hypothesis, we analyzed

Indexed as

Alzheimer’s diseasebiomarkerscognitionlongitudinalPETplasma

Identifiers

PMID39867392
PMCPMC11759618

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.