Evidence map›Paper›PMID 39867359›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Plasma Proteomic Signatures of Physical Activity Provide Insights into Biological Impacts of Physical Activity and its Protective Role Against Dementia.

Gayatri Arani, Amit Arora, Shuai Yang, Jingyue Wu, Jennifer N Kraszewski, Amy Martins, Alexandra Miller, Zebunnesa Zeba, Ayan Jafri, Chengcheng Hu and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Gayatri AraniDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-2372-9086
Amit AroraDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.ORCID 0009-0001-8841-0316
Shuai YangDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.
Jingyue WuDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.
Jennifer N KraszewskiDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.
Amy MartinsDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.
Alexandra MillerDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.
Zebunnesa ZebaDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.ORCID 0000-0002-5967-5972
Ayan JafriDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.
Chengcheng HuDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.ORCID 0000-0001-8525-0356
Leslie V FarlandDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.ORCID 0000-0001-7455-8531
Jennifer W BeaDepartment of Health Promotion Sciences, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-9868-1574
Dawn K ColettaDepartment of Physiology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0001-5819-5152
Daniel H AslanDepartment of Anthropology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-3694-7218
M Katherine SayreDepartment of Anthropology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-2554-4058
Pradyumna K BharadwajDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Madeline AllyDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Silvio MaltagliatiDepartment of Anthropology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-7199-0599
Mark H C LaiDepartment of Anthropology, University of Southern California, Los Angeles, CA, USA.
Rand WilcoxDepartment of Psychology, University of Southern California, Los Angeles, CA, United States.ORCID 0000-0002-2524-2976
Eco de GeusDepartment of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.ORCID 0000-0001-6022-2666
Gene E AlexanderDepartment of Psychology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-6476-5606
David A RaichlenDepartment of Anthropology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-4940-7886
Yann C KlimentidisDepartment of Epidemiology and Biostatistics, College of Public Health, University of Arizona, Tucson, AZ, USA.ORCID 0000-0002-6065-4044

Funding

Inactivity, sedentary behavior, and the risk for Alzheimer’s disease in middle aged to older adultsR01AG072445 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GENE E ALEXANDER, Yann Charles Klimentidis · 2022 to 2026
$3.3M
NIA NIH HHS R01 AG072445
6 · The paper itself

Abstract

Physical activity (PA), including sedentary behavior, is associated with many diseases, including Alzheimer's disease and all-cause dementia. However, the specific biological mechanisms through which PA protects against disease are not entirely understood. To address this knowledge gap, we first assessed the conventional observational associations of three self-reported and three device-based PA measures with circulating levels of 2,911 plasma proteins measured in the UK Biobank (n

Identifiers

PMID39867359
PMCPMC11759254

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.