Evidence map›Paper›PMID 39867128›Full record

ArticleFrontiers in toxicology2024

A primary rat neuron-astrocyte-microglia tri-culture model for studying mechanisms of neurotoxicity.

Jessie R Badley, Aishwarya Bhusal, Pamela J Lein

Abstract read
In one paragraph

Article in Frontiers in toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jessie R BadleyDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, United States.
Aishwarya BhusalDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, United States.
Pamela J LeinDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, United States.

Funding

Molecular and Cellular Basis of PCB Developmental Neurotoxicity: ViCTER supplementR01ES014901 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HANS-JOACHIM LEHMLER, Pamela J Lein · 2009 to 2026
$9.3M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
Initiative for Maximizing Student Development at the University of California, Davis.T32GM135741 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ALDRIN V. GOMES, Manuel F Navedo · 2020 to 2026
$3.2M
Traffic-related air pollution exacerbates AD-relevant phenotypes in a genetically susceptible rat model via neuroinflammatory mechanism(s)RF1AG074709 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BEIN, KEITH, LEIN, PAMELA J · 2021 to 2021
$2.3M
Investigating the cellular and molecular mechanisms of lower-chlorinated polychlorinated biphenyl developmental neurotoxicityF31ES035282 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BADLEY, JESSIE RENEE · 2023 to 2024
$82k
NIA NIH HHS RF1 AG074709NIEHS NIH HHS F31 ES035282NIEHS NIH HHS R01 ES014901NIEHS NIH HHS T32 ES007059NIGMS NIH HHS T32 GM135741
6 · The paper itself

Abstract

Primary cell cultures from rodent brain are widely used to investigate molecular and cellular mechanisms of neurotoxicity. To date, however, it has been challenging to reliably culture endogenous microglia in dissociated mixed cultures. This is a significant limitation of most

Indexed as

cortical neuronsin vitro modelneuroinflammationneurotoxicityrat

Identifiers

PMID39867128
PMCPMC11759268

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.