ArticleInternational journal of clinical pediatric dentistry2024
Estimation and Correlation of Human Leukocyte Antigen-DR and Human Leukocyte Antigen-DQ in Children with and without Severe-early Childhood Caries: A Randomized Clinical Trial.
Article in International journal of clinical pediatric dentistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/aim: Early childhood caries (ECC) is a prevalent dental disease, influenced by genetic and environmental factors. Human leukocyte antigens (HLA) have been suggested as a predisposing factor. This study aims to estimate and correlate HLA-DR and HLA-DQ activity in the saliva of caries-active and caries-free children, potentially aiding disease diagnosis and prevention. Materials and methods: A comparative study was performed on 50 children, divided into two groups: caries-active and caries-free, consisting of 25 children each, aged 3-6 years. Unstimulated saliva samples were collected and subjected to enzyme-linked immunosorbent assay (ELISA) for analysis. HLA-DR and HLA-DQ levels will be estimated and correlated with caries score, age, and gender. Results: HLA-DR level was 33.032 ± 2.869 pg/mL in the caries-active group and 5.288 ± 0.960 pg/mL in the caries-free group, and was statistically significant at Conclusion: Results suggest a substantial correlation between HLA-DR level and the severity of dental caries, and an increase in HLA-DR may be linked to an increase in caries severity. Thus, HLA-DR detection as a molecular biomarker for early diagnosis of ECC may be recommended. How to cite this article: Thimmegowda U, Dhamnekar P. Estimation and Correlation of Human Leukocyte Antigen-DR and Human Leukocyte Antigen-DQ in Children with and without Severe-early Childhood Caries: A Randomized Clinical Trial. Int J Clin Pediatr Dent 2024;17(12):1346-1351.
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