Evidence map›Paper›PMID 39866936›Full record

ArticleEJHaem2025

Myeloproliferative neoplasm harboring both monosomy 7 and an

Hideki Yoshida, Shinya Osone, Madoka Konishi, Seiji Tanaka, Tohru Inaba, Toshihiko Imamura, Tomoko Iehara

Abstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hideki YoshidaDepartment of Pediatrics Kyoto Prefectural University of Medicine Kyoto Japan.ORCID https://orcid.org/0000-0001-8140-627X
Shinya OsoneDepartment of Pediatrics Kyoto Prefectural University of Medicine Kyoto Japan.
Madoka KonishiDepartment of Pediatrics Kyoto Prefectural University of Medicine Kyoto Japan.
Seiji TanakaDepartment of Pediatrics Kyoto Prefectural University of Medicine Kyoto Japan.
Tohru InabaDepartment of Infection Control and Laboratory Medicine Kyoto Prefectural University of Medicine Kyoto Japan.
Toshihiko ImamuraDepartment of Pediatrics Kyoto Prefectural University of Medicine Kyoto Japan.
Tomoko IeharaDepartment of Pediatrics Kyoto Prefectural University of Medicine Kyoto Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We present a case of a 9-year-old girl diagnosed with a myeloproliferative neoplasm (MPN) harboring both monosomy 7 and an ALK/ROS1 fusion gene. Case presentation: The neoplasm was resistant to conventional AML chemotherapy and required hematopoietic cell transplantation (HCT) to achieve remission. Discussion: MPNs with monosomy 7 and ALK/ROS1 fusions occur in a wide age range of children and adults, and require HCT for long-term remission. Furthermore, these cases can be responsive to ALK inhibitors. Conclusion: This report underscores the potential need to reclassify such MPNs as a distinct entity, which has unique therapeutic implications.

Indexed as

ALK inhibitorALK/ROS1hematopoietic cell transplantationmonosomy 7myeloproliferative neoplasm

Identifiers

PMID39866936
PMCPMC11756977

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.