Evidence map›Paper›PMID 39866924›Full record

ArticleEJHaem2025

Factors related to mean corpuscular volume in

James C Barton, J Clayborn Barton, Ronald T Acton

Abstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Mean Corpuscular Volume inJournal of hematology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James C BartonDepartment of Medicine University of Alabama at Birmingham Birmingham Alabama USA.ORCID https://orcid.org/0000-0003-2876-8276
J Clayborn BartonSouthern Iron Disorders Center Birmingham Alabama USA.
Ronald T ActonSouthern Iron Disorders Center Birmingham Alabama USA.

Funding

Zevalin Radioimmunotherapy Using a Modified TreatmentM01RR000032 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICH, ROBERT R. · 1985 to 2008
$23.6M
IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSISN01HC005185 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ECKFELDT, JOHN H · 2000 to 2000
$1.1M
IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSIS STUDYN01HC005190 · HC · UNIVERSITY OF CALIFORNIA IRVINE · PI MCLAREN, CHRISTINE E · 2000 to 2000
$338k
IRON OVERLOAD AND HEREDITARY HEMOCHROMOTOSIS STUDYN01HC005188 · HC · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ACTON, RONALD T. · 2000 to 2000
$256k
IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSISN01HC005186 · HC · HOWARD UNIVERSITY · PI GORDEUK, VICTOR R · 2000 to 2000
$223k
IRON OVERLOAD AND HEREDITARY HEMOCHROMATOSIS STUDY-FIELDN01HC005191 · HC · LONDON HEALTH SCIENCES CENTER · PI ADAMS, PAUL · 2000 to 2000
$218k
NCRR NIH HHS M01 RR000032NHLBI NIH HHS N01 HC005185NHLBI NIH HHS N01 HC005186NHLBI NIH HHS N01 HC005188NHLBI NIH HHS N01 HC005190NHLBI NIH HHS N01 HC005191
6 · The paper itself

Abstract

Introduction: The aim of this study was to define the relationships between factors other than transferrin saturation (TS) to mean corpuscular volume (MCV) and macrocytosis (MCV > 100 fL) in Methods: We studied white post-screening participants with p.C282Y homozygosity who did not have anemia, report cirrhosis or pregnancy, or use medications that increase MCV. We analyzed relations of MCV and macrocytosis with age, sex, diabetes reports, daily alcohol consumption, swollen or tender 2nd/3rd metacarpophalangeal (MCP) joints, TS, and serum ferritin (SF). Results: There were 257 participants (110 men and 147 women). Median alcohol consumption, median TS, median SF, and macrocytosis prevalence were significantly greater in men. Relative risk of macrocytosis in men was 2.81. In men and women, there were significant positive Pearson's correlations of MCV versus age and Spearman's correlations of MCV versus alcohol consumption and TS. Mean MCV and macrocytosis prevalence were significantly greater in participants with than without swollen or tender 2nd/3rd MCP joints. Linear regression on MCV revealed positive associations: age ( Conclusions: MCV in

Indexed as

alcohol consumptionerythrocytehemochromatosisironmacrocytosistransferrin saturation

Identifiers

PMID39866924
PMCPMC11756985

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.