Evidence map›Paper›PMID 39866884›Full record

ArticleResearch square2025

Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma.

Ken Young, Wen-Yu Shi, Zijun Xu-Monette, Youchao Jia, Alexandar Tzankov, Heounjeong Go, Ling Li, Maurilio Ponzoni, Yafei Wang, Qiongli Zhai and 32 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

42 authors.

Ken YoungDuke University Medical Center and Duke Cancer Institute.ORCID 0000-0002-5755-8932
Wen-Yu ShiRui Jin hospital.
Zijun Xu-MonetteDuke University School of Medicine.
Youchao JiaDuke University Medical Center.
Alexandar TzankovUniversity Hospital Basel.ORCID 0000-0002-1100-3819
Heounjeong GoAsan Medical Center, University of Ulsan College of Medicine.ORCID 0000-0003-0412-8709
Ling LiFirst Affiliated Hospital of Zhengzhou University.
Maurilio Ponzonisan raffaele scientific institute.
Yafei WangTianjin Medical University.
Qiongli ZhaiTianjin Cancer Center Hospital.
Anamarija Perry
Shi WangNational University Hospital, Singapore.
Xiaoxiao WangThe University of Texas MD Anderson Cancer Center.
April ChiuMayo Clinic.
Mina XuYale University.ORCID 0000-0001-9513-245X
Carlo ViscoUniversity of Verona.
Karen DybkaerAalborg Hospital, Aarhus University Hospital.ORCID 0000-0003-2488-435X
Henry WithersRoswell Park Comprehensive Cancer Center.ORCID 0000-0002-9746-9352
Mark LongRoswell Park Comprehensive Cancer Center.
Alyssa YuanDuke University Medical Center.
Yi MiaoFirst Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital.
Jianyong LiFirst Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Personalized Cancer Medicine.ORCID 0000-0002-9931-4055
Everardo MaciasDuke University Medical Center.
Wen ShuaiDuke University Medical Center.
Bangchen WangDuke University Medical Center.
Govind BhagatColumbia University Irving Medical Center.ORCID 0000-0001-6250-048X
Youli Zu
Zenggang PanUniversity of Colorado Anschutz Medical Campus.
William ChoiTuen Mun Hospital.
Santiago Montes-MorenoHospital Universitario Marqués de Valdecilla/IDIVAL.
Weina ChenUT Southwestern Medical Center.ORCID 0000-0001-5638-4371
J Han van KriekenRadboud university medical center Nijmegen.
Michael MøllerOdense University Hospital.ORCID 0000-0003-2041-3630
Fenghuang ZhanMyeloma Center, University of Arkansas for Medical Sciences.ORCID 0000-0001-5417-2973
Ben ParsonsGundersen Lutheran Health System.
Shanxiang ZhangUniversity of Nebraska Medical Center.
Eric HsiMayo Clinic.
Aliyah SohaniMassachusetts General Hospital.ORCID 0000-0002-6307-4854
Jeremy AbramsonHarvard Medical School.
Andrés FerreriIRCCS San Raffaele Scientific Institute.ORCID 0000-0001-9606-6124
Bing XuThe First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University.ORCID 0000-0002-7271-4438
Yong LiBaylor College of Medicine.ORCID 0000-0001-8838-1714

Funding

Prevention of MGUS Progression to MM by Modulating the Bone Marrow MicroenvironmentU54CA272691 · NCI · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI John Damian Shaughnessy · 2023 to 2026
$6.1M
Genetic and Epigenetic Biomarkers for B-cell LymphomaR01CA233490 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YOUNG, KEN H. · 2019 to 2023
$1.8M
NCI NIH HHS R01 CA233490NCI NIH HHS U54 CA272691
6 · The paper itself

Abstract

Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive lymphoma with molecular heterogeneity not well characterize. In this study, we performed next-generation sequencing analysis for a large number of DNA and RNA samples from patients with PT-DLBCL. DNA sequencing analysis identified ≥ 3 chromosomes with copy number variations (CNVs) and microsatellite instability as prognostic biomarkers, rather than

Indexed as

BCRCIBERSORTclusteringCNVDLBCLepigeneticgene signaturegenetic alterationGEPIP-LBCLMCDmicroRNAMSIMYD88NGSprofilingPTLRNA-seqsubtypingtesticular lymphomatestisTMETP53 mutation

Identifiers

PMID39866884
PMCPMC11760253

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.