Evidence map›Paper›PMID 39866873›Full record

ArticleResearch square2025

Hierarchical Neurocognitive Model of Externalizing and Internalizing Comorbidity.

Tianye Jia, Chao Xie, Shitong Xiang, Yueyuan Zheng, Chun Shen, Yuzhu Li, Wei Cheng, Nilakshi Vaidya, Zuo Zhang, Lauren Robinson and 46 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors.

Tianye JiaFudan University.ORCID 0000-0001-5399-2953
Chao XieInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University.
Shitong XiangInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University.ORCID 0000-0002-5513-4714
Yueyuan ZhengDivision of Social Science, Hong Kong University of Science and Technology Fudan Univerisity.
Chun ShenFudan University.
Yuzhu LiFudan University.
Wei ChengFudan University.ORCID 0000-0003-1118-1743
Nilakshi VaidyaCharité Universitätsmedizin Berlin.ORCID 0000-0002-4600-7158
Zuo ZhangKing's College London.ORCID 0000-0002-6752-3434
Lauren RobinsonOxford.
Jeanne WintererDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, Germany.
Yuning ZhangKing's College London.
Sinead KingDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Gareth BarkerDepartment of Neuroimaging, King's College London.ORCID 0000-0002-5214-7421
Arun BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0003-0114-4914
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt.ORCID 0000-0003-0111-5996
Hedi KebirCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Germany.
Dongtao WeiKey Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.
Eric ArtigesINSERM/Université Paris-Saclay.ORCID 0000-0003-4461-7646
Marina BobouSocial Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
M BroulidakisDepartment of Psychiatry, University of Southampton, United Kingdom.
Tobias BanaschewskiCentral Institute of Mental Health, Mannheim.ORCID 0000-0003-4595-1144
Andreas BeckerDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Christian BuchelUniversity Medical Center Hamburg-Eppendorf.ORCID 0000-0003-1965-906X
Patricia ConrodUniversity of Montreal, Canada.ORCID 0000-0002-5570-481X
Tahmine FadaiUniversity Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Hamburg, Germany.
Herta FlorCentral Institute of Mental Health Medical Faculty Mannheim Heidelberg University.ORCID 0000-0003-4809-5398
Antoine Grigis
Yvonne GrimmerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Hugh GaravanUniversity of Vermont.ORCID 0000-0002-8939-1014
Penny GowlandUniversity of Nottingham.ORCID 0000-0002-4900-4817
Andreas HeinzCharité Universitätsmedizin, Berlin.ORCID 0000-0001-5405-9065
Corinna InsenseeGeorg-Elias-Müller-Institute of Psychology, Department of Clinical Psychology and Psychotherapy, University of Göttingen, Gosslerstraße 14, 37073 Göttingen, Germany.
Viola KappelDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany.
Hervé LemaîtreGroupe d'Imagerie Neurofonctionnelle.ORCID 0000-0002-5952-076X
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale.ORCID 0000-0002-0136-0388
Marie-Laure MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS.
Betteke NoortDepartment of Psychology, MSB Medical School Berlin, Rüdesheimer Str. 50, 14197 Berlin, Germany.
Frauke NeesUniversity Medical Center Schleswig-Holstei, n Kiel University.ORCID 0000-0002-7796-8234
Dimitri Papadopoulos OrfanosORCID 0000-0002-1242-8990
Jani PenttiläDepartment of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic Kauppakatu 14, Lahti, Finland.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Gottingen.
Juliane FrohnerDepartment of Psychiatry and Psychotherapy, Technische Universitat Dresden, Dresden, Germany.ORCID 0000-0002-8493-6396
Ulrike SchmidtKing's College London.
Julia SinclairUniversity of Southampton.ORCID 0000-0002-1905-2025
Michael SmolkaTechnische Universität Dresden.ORCID 0000-0001-5398-5569
Maren StruveDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Mannheim, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Be.ORCID 0000-0002-9403-6121
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.
Jiang QiuSouthwest University.
Peng XieThe First Affiliated Hospital of Chongqing Medical University.ORCID 0000-0002-0081-6048
Barbara SahakianUniversity of Cambridge.ORCID 0000-0001-7352-1745
Trevor RobbinsUniversity of Cambridge.ORCID 0000-0003-0642-5977
Sylvane DesrivièresInstitute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom.ORCID 0000-0002-9120-7060
Gunter SchumannCharite Universitaetsmedizin Berlin.ORCID 0000-0002-7740-6469
Jianfeng FengFudan University.ORCID 0000-0001-5987-2258

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238
6 · The paper itself

Abstract

Mounting evidence suggests hierarchical psychopathology factors underlying psychiatric comorbidity. However, the exact neurobiological characterizations of these multilevel factors remain elusive. In this study, leveraging the brain-behavior predictive framework with a 10-year longitudinal imaging-genetic cohort (IMAGEN, ages 14, 19 and 23,

Identifiers

PMID39866873
PMCPMC11760247

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.