Evidence map›Paper›PMID 39866872›Full record

ArticleResearch square2025

Transcriptional regulation of the non-homologous end joining gene Ligase IV by an intronic regulatory element directs thymocyte development.

Matthew D Estrada, Christopher J Gebhardt, Mariam Salem, Kruthika Sharma, Craig H Bassing, Eugene M Oltz, Patrick L Collins

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Matthew D EstradaDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, 43210, USA.
Christopher J GebhardtDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, 43210, USA.
Mariam SalemDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, 43210, USA.
Kruthika SharmaDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, 43210, USA.
Craig H BassingDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Eugene M OltzDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, 43210, USA.
Patrick L CollinsDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, 43210, USA.ORCID 0000-0003-4550-4272

Funding

Topological Control of Antigen Receptor Loci during Lymphocyte DevelopmentR01AI130231 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI BASSING, CRAIG H, OLTZ, EUGENE M · 2017 to 2021
$3.8M
TOPOLOGICAL MECHANISMS OF DNA BREAK REPAIR IN LYMPHOCYTESR37AI118852 · NIAID · OHIO STATE UNIVERSITY · PI Eugene M Oltz · 2021 to 2026
$2.8M
TOPOLOGICAL MECHANISMS OF DNA BREAK REPAIR IN LYMPHOCYTESR01AI118852 · NIAID · WASHINGTON UNIVERSITY · PI OLTZ, EUGENE M · 2015 to 2019
$1.9M
Gene regulatory architecture of CD56 bright natural killer cellsR21AI156411 · NIAID · OHIO STATE UNIVERSITY · PI COLLINS, PATRICK LEONARD · 2021 to 2022
$433k
NIAID NIH HHS R01 AI118852NIAID NIH HHS R01 AI130231NIAID NIH HHS R21 AI156411NIAID NIH HHS R37 AI118852
6 · The paper itself

Abstract

Double-strand breaks represent the most dangerous form of DNA damage, and in resting cells, these breaks are sealed via the non-homologous end joining (NHEJ) factor Ligase IV (LIG4). Excessive NHEJ may be genotoxic, necessitating multiple mechanisms to control NHEJ activity. However, a clear mechanism of transcriptional control for them has not yet been identified. Here, we examine mechanisms governing

Indexed as

cis-regulatory elementdouble-strand break responsegene regulationLigase IVNon-homologous end joiningV(D)J recombination

Identifiers

PMID39866872
PMCPMC11760251

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.