Evidence map›Paper›PMID 39866870›Full record

ArticleResearch square2025

Structure-guided optimization of small molecules targeting the yeast casein kinase, Yck2, as a therapeutic strategy to combat Candida albicans.

Leah Cowen, Emily Puumala, Meganathan Nandakumar, Bonnie Yiu, Peter Stogios, Benjamin Strickland, Robert Zarnowski, Xiaoyu Wang, Noelle Williams, Alexei Savchenko and 4 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Leah CowenUniversity of Toronto.ORCID 0000-0001-5797-0110
Emily PuumalaUniversity of Toronto.
Meganathan NandakumarUniversity of North Carolina at Chapel Hill.
Bonnie YiuUniversity of Toronto.
Peter StogiosUniversity of Toronoto.ORCID 0000-0001-8663-1425
Benjamin StricklandUniversity of North Carolina at Chapel Hill.
Robert ZarnowskiUniversity of Wisconsin-Madison.ORCID 0000-0001-6343-1500
Xiaoyu WangUT Southwestern Medical Center.
Noelle WilliamsThe University of Texas Southwestern Medical Center at Dallas.
Alexei SavchenkoUniversity of Calgary.ORCID 0000-0002-5256-9237
David AndesUniversity of Wisconsin.ORCID 0000-0002-7927-9950
Nicole RobbinsUniversity of Toronto.
Luke WhitesellUniversity of Toronto.
Timothy WillsonUniversity of North Carolina at Chapel Hill.ORCID 0000-0003-4181-8223

Funding

TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.75N93022C00035 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SATCHELL, KARLA · 2022 to 2025
$20.7M
Targeting the casein kinase 1 (CK1)-like kinase Yck2 in fungal pathogenesisR01AI162789 · NIAID · UNIVERSITY OF TORONTO · PI LEAH Elizabeth Cowen, Timothy M Willson · 2022 to 2026
$3.1M
Request for a 500 MHz NMR console and nitrogen-cooled cryoprobeS10OD032476 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEE, ANDREW L · 2022 to 2022
$599k
NIAID NIH HHS 75N93022C00035NIAID NIH HHS R01 AI162789NIH HHS S10 OD032476
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39866870
PMCPMC11760248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.