ArticleTherapeutic advances in neurological disorders2025
Oral supplementation with propionate is reflected in the serum of healthy individuals.
Article in Therapeutic advances in neurological disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Short-chain fatty acids (SCFAs), including propionic acid (PA), are key in immunological research. Supplementing PA has shown benefits for autoimmune diseases. A comprehensive understanding of the PA pharmacokinetics is essential for the optimal design and execution of studies utilizing orally administered PA. Objective: We propose two methods of measuring PA in serum, carried out by different laboratories. Design: Blood samples from 20 volunteers were collected hourly following PA supplementation. Methods: Serum propionate quantification was performed with two independent mass spectrometry-based (MS) analyses, including liquid-chromatography (LC)-MS and direct-infusion (DI)-MS. Results: PA levels increased within 1 h of ingestion of 500 mg PA. Serum concentrations ranged from 1.3 to 4.5 µmol/L, rising significantly after 1 h ( Conclusion: The shown pharmacokinetics can be used in future PA research.
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