ArticleACS omega2025
Real-Time Monitoring of Electrode Surface Changes in Fast-Scan Cyclic Voltammetry Using Fourier Transform Electrochemical Impedance Spectroscopy.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Effects of oxycodone on tonic levels and phasic release of serotonin in the rat nucleus accumbens core.Bioelectrochemistry (Amsterdam, Netherlands) · 2026Article
- Controlled Debundling of Single-Walled Carbon Nanotubes (SWCNTs) by Au@Pt Nanorods Enables Mechanism-Dependent Electrochemical Sensing and Biofouling Response.Analytical chemistry · 2026Article
- Measuring vancomycin using paired pulse voltammetry with a wireless instantaneous neurotransmitter concentration sensing system for point-of-care patient treatment.Biomedical engineering letters · 2026Article
- Electrochemical impedance spectroscopy for characterizing neural electrodes.Current opinion in electrochemistry · 2026Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Fast-scan cyclic voltammetry (FSCV) is a widely used electrochemical technique to measure the phasic response of neurotransmitters in the brain. It has the advantage of reducing tissue damage to the brain due to the use of carbon fiber microelectrodes as well as having a high temporal resolution (10 Hz) sufficient to monitor neurotransmitter release in vivo. During the FSCV experiment, the surface of the carbon fiber microelectrode is inevitably changed by the fouling effect. In terms of redox peak potential and sensitivity against neurotransmitters, a changed electrode surface results in a voltammogram that differs from the precalibration. However, when an electrode is implanted in the brain, the method for monitoring the electrode status change is limited. In this study, we propose employing an electrochemical impedance concept to monitor the gradual change of the electrode surface during FSCV scanning. Fourier transform electrochemical impedance spectroscopy (FTEIS) was used in combination with FSCV to detect the real-time impedance of the electrode. The relationship between impedance and electrode surface conditions was studied by immersing carbon fiber microelectrodes in bovine serum albumin solution to induce biofouling and diminish electrode sensitivity. As a result of the nonspecific adsorption of bovine serum albumin during the interleave scan of FSCV and FTEIS, both the measured dopamine response and the capacitance of the equivalent circuit model from FTEIS decreased over time. The capacitance and sensitivity of the electrode showed correlation (R
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Registered trials
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