Evidence map›Paper›PMID 39866556›Full record

ArticlePeerJ2025

A nociceptor-specific RNAi screen in

Amber Dyson, Gita Gajjar, Katherine C Hoffman, Dakota Lewis, Sara Palega, Erik Rangel Silva, James Auwn, Andrew Bellemer

Abstract read
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amber DysonDepartment of Biology, Appalachian State University, Boone, North Carolina, United States.
Gita GajjarDepartment of Biochemistry and Molecular Biology, East Carolina University, Greenville, North Carolina, United States.
Katherine C HoffmanDepartment of Biology, Appalachian State University, Boone, North Carolina, United States.
Dakota LewisDepartment of Biology, Appalachian State University, Boone, North Carolina, United States.
Sara PalegaDepartment of Biology, Appalachian State University, Boone, North Carolina, United States.
Erik Rangel SilvaDepartment of Biology, Appalachian State University, Boone, North Carolina, United States.
James AuwnDepartment of Biology, Appalachian State University, Boone, North Carolina, United States.ORCID 0009-0007-8999-0184
Andrew BellemerDepartment of Biology, Appalachian State University, Boone, North Carolina, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nociception is the process by which sensory neurons detect and encode potentially harmful environmental stimuli to generate behavioral responses. Nociceptor neurons exhibit plasticity in which their sensitivity to noxious stimuli and subsequent ability to drive behavior may be altered by environmental conditions, injury, infection, and inflammation. In some cases, nociceptor sensitization requires regulated changes in gene expression, and recent studies have indicated roles for post-transcriptional mechanisms in regulating these changes as an aspect of nociceptor plasticity. The larvae of

Indexed as

Drosophila melanogasterDrosophila ProteinsNociceptionNociceptorsRNA-Binding ProteinsRNA InterferenceAnimalsHot TemperatureLarvaDrosophila ProteinsRNA-Binding ProteinsDrosophilaGene ExpressionNeurobiologyNociceptionRNA-binding Proteins

Identifiers

PMID39866556
PMCPMC11759608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.