ArticleFrontiers in neurology2024
The correlation between intracranial atherosclerosis and white matter hyperintensities in cerebral small vessel disease: a high-resolution magnetic resonance imaging study.
Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Integrated imaging assessment of large arteries, intracranial plaque, and cerebral small vessel disease to distinguish acute ischemic stroke from transient ischemic attack.Neuroradiology · 2026Article
- Association and Risk-Stratification Value of the Positive Remodeling Index of Middle Cerebral Artery Atherosclerotic Plaques for Perforator-Territory Infarction Based on High-Resolution Magnetic Resonance Imaging.Revista de neurologia · 2026Article
- Association of Intracranial Plaque Features with the Severity of White Matter Hyperintensities in Middle-Aged and Older Community-Dwelling Adults.Biomedicines · 2025Article
- The mediating role of white matter hyperintensity in the association between malnutrition and cognitive impairment in patients with cerebral small vessel disease.Frontiers in neurologyArticle
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9 authors.
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Abstract
Objective: Recent studies have indicated a close relationship between intracranial arterial stenosis and white matter hyperintensities (WMHs), but few have reported on the correlation between the characteristics of intracranial arterial wall plaques and WMHs. The aim of this study was to comprehensively assess the correlation between intracranial atherosclerosis plaques and WMHs using 3.0T high-resolution magnetic resonance imaging (HR-MRI). Patients and methods: Ninety-two ischemic stroke patients with middle cerebral artery (MCA) stenosis <50% on cranial magnetic resonance angiography (MRA) underwent conventional MRI and HR-MRI examinations. T2-weighted fluid-attenuated inversion recovery (T2-FLAIR) images were processed using 2D VBNeT automatic segmentation technology to segment WMH volume. HR-MRI images were analyzed using ImageJ software to evaluate the luminal area, outer wall area, plaque distribution, luminal stenosis rate, remodeling patterns, and other plaque parameters at the stenosis site and reference points of the MCA M1 segment. The correlation between the presence of plaques, plaque distribution, luminal stenosis rate, T1 hyperintensity, remodeling patterns, remodeling ratio (RR), eccentric plaques, and plaque burden with the volume of cerebral WMHs was analyzed. Results: Compared with the no-plaque group, the plaque group had significantly higher age, male ratio, total WMH volume, periventricular WMH (PVWMH) volume, deep WMH (DWMH) volume, and juxtacortical WMH (JCWMH) volume (all Conclusion: The presence of intracranial atherosclerotic plaques, plaque distribution, and positive remodeling are closely associated with increased cerebral WMHs burden in patients with ischemic stroke, which further supports the relationship between large artery atherosclerosis and CSVD.
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