Evidence map›Paper›PMID 39866492›Full record

ArticleHeliyon2025

Investigating POU3F4 in cancer: Expression patterns, prognostic implications, and functional roles in tumor immunity.

Weiwei Chen, Yaya Ji, Rui Wang, Ruijie Ji, Yujian Lin, Yuhang Wu, Lehan Liu, Tianle Sha, Wen Li, Lei Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Weiwei ChenDepartment of Cardiothoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, 224002, China.
Yaya JiDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Rui WangDepartment of Cardiothoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, 224002, China.
Ruijie JiDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Yujian LinDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Yuhang WuDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Lehan LiuDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Tianle ShaDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Wen LiDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Lei ZhangDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Longfei YangDepartment of Anatomy, Institute of Neurobiology, Medical School, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Xinhua ZhangDepartment of Cardiothoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, 224002, China.
Jianxiang SongDepartment of Cardiothoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng, 224002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research has demonstrated that POU3F4 is integral to various cancers, in addition to its significance in inner ear development, pancreatic differentiation, as well as neural stem cell differentiation. Nevertheless, comprehensive pan-cancer analyses focusing on POU3F4 remain limited. This study aims to assess the prognostic value of POU3F4 in thirty-three cancers and explore its immune-related functions. Based on data from The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), Genotype-Tissue Expression (GTE), and Gene Set Cancer Analysis (GSCA), we employed various bioinformatics approaches to investigate the potential carcinogenic effects of POU3F4. Our study encompassed DNA methylation, RNA methylation, tumor mutation burden (TMB), mismatch repair (MMR) genes, microsatellite instability (MSI), the relationship between POU3F4 and prognosis, and immune cell infiltration (ICI) across different tumors. The analysis revealed that POU3F4 expression is typically low in most cancers but is elevated in breast invasive carcinoma, glioblastoma multiforme (GBM), liver hepatocellular carcinoma, and thyroid carcinoma, with the highest levels in GBM. Additionally, POU3F4 expression correlates with cancer prognosis, either positively or negatively. The expression of POU3F4 demonstrated significant associations with MSI in four cancers and TMB in six cancers. POU3F4 expression was significantly linked to DNA methylation in 13 cancer types and RNA methylation in most cancers. It also correlated with the tumor immune microenvironment, immune-related genes, immune checkpoint inhibitors, and drug resistance in various cancers.

Indexed as

Drug resistancePan-cancer analysisPOU3F4Prognostic signatureTumor immunity

Identifiers

PMID39866492
PMCPMC11760290

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.