Evidence map›Paper›PMID 39866409›Full record

ArticleHeliyon2025

TAS2R38 genotype and CRS severity in children with cystic fibrosis.

Elena Cantone, Antonella Tosco, Angela Sepe, Valeria Raia, Rossella Negri, Alice Castaldo, Chiara Cimbalo, Paolo Pezzella, Mario Brandon Russo, Giusi Grimaldi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elena CantoneDepartment of Neuroscience, Reproductive and Dentistry Science, ENT section, "Federico II University of Naples", Naples, Italy.
Antonella ToscoPaediatric Unit, Department of Maternal and Child Health, Cystic Fibrosis Regional Reference Center, A.O.U. Federico II, Naples, Italy.
Angela SepePaediatric Unit, Department of Maternal and Child Health, Cystic Fibrosis Regional Reference Center, A.O.U. Federico II, Naples, Italy.
Valeria RaiaPaediatric Unit, Department of Maternal and Child Health, Cystic Fibrosis Regional Reference Center, A.O.U. Federico II, Naples, Italy.
Rossella NegriPaediatric Unit, Department of Maternal and Child Health, Cystic Fibrosis Regional Reference Center, A.O.U. Federico II, Naples, Italy.
Alice CastaldoPaediatric Unit, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Chiara CimbaloPaediatric Unit, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Paolo PezzellaDepartment of Neuroscience, Reproductive and Dentistry Science, ENT section, "Federico II University of Naples", Naples, Italy.
Mario Brandon RussoDepartment of Engineering, University of Campania "Luigi Vanvitelli", Aversa, Italy.
Giusi GrimaldiDepartment of Neuroscience, Reproductive and Dentistry Science, ENT section, "Federico II University of Naples", Naples, Italy.
Claudio Di NolaDepartment of Neuroscience, Reproductive and Dentistry Science, ENT section, "Federico II University of Naples", Naples, Italy.
Luigi GrecoPaediatric Unit, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cystic fibrosis is a heterogeneous disease whose severity and symptoms largely depend on the functional impact of mutations in the cystic fibrosis transmembrane conductance regulator gene. Other genes may also modulate the clinical manifestations and complications associated with cystic fibrosis. Genetic variants of the bitter taste receptor TAS2R38 have been shown to contribute to the susceptibility and severity of chronic rhinosinusitis. This study aims to elucidate the role of Methods: This retrospective observational case-control study evaluated sinus clinical features, quality of life, and the occurrence of Results: The non-taster genetic variant of bitter taste receptor TAS2R38 was associated with greater severity of chronic rhinosinusitis, as measured by endoscopic and radiological scores, compared to the taster variant (p = 0.031 and p = 0.03, respectively). Furthermore, an inverse correlation was observed between the age at first Conclusions: The findings highlight the role of

Indexed as

Bitter receptorChronic rhinosinusitisCystic fibrosisPseudomonas aeruginosaTAS2R38

Identifiers

PMID39866409
PMCPMC11761314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.