Evidence map›Paper›PMID 39866302›Full record

ArticleReumatologia2024

New inflammatory markers associated with disease activity in rheumatoid arthritis: pan-immune-inflammation value, systemic immune-inflammation index, and systemic inflammation response index.

İpek Okutan, Recai Aci, Âdem Keskin, Melek Bilgin, Halit Kızılet

Abstract read
In one paragraph

Article in Reumatologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

İpek OkutanDepartment of Physical Medicine and Rehabilitation, Samsun University Faculty of Medicine, Turkey.ORCID https://orcid.org/0000-0002-8402-8806
Recai AciDepartment of Medical Services and Techniques, Aydın Adnan Menderes University, Söke Vocational School of Health Services, Turkey.ORCID https://orcid.org/0000-0002-1517-3356
Âdem KeskinDepartment of Medical Services and Techniques, Aydın Adnan Menderes University, Aydın Vocational School of Health Services, Turkey.ORCID https://orcid.org/0000-0003-1921-2583
Melek BilginDepartment of Medical Microbiology, Samsun University Faculty of Medicine, Turkey.ORCID https://orcid.org/0000-0003-0025-8717
Halit KızıletAydın Adnan Menderes University, Söke Vocational School of Health Services, Aydın, Turkey.ORCID https://orcid.org/0000-0002-7289-4635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study aimed to investigate the relationship between the pan-immune-inflammation value (PIV), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) and disease activity in rheumatoid arthritis (RA), characterized by chronic inflammation and immune system involvement, and to provide new insights into the clinical implications of RA. Material and methods: A total of 148 participants, including 97 RA patients (both newly diagnosed and established cases) and 51 healthy controls, were included in the study. Disease severity was assessed using the Disease Activity Score 28 (DAS28), and the relationship between DAS28 and PIV, SII, and SIRI, obtained from complete blood count results, was investigated. Additionally, C-reactive protein and erythrocyte sedimentation rate measurements were included in the study. Results: The average age of RA patients was significantly higher than that of healthy individuals ( Conclusions: The findings revealed that PIV, SII, and SIRI were elevated in individuals with RA and may serve as complementary diagnostic markers. PIV, SII, and SIRI, as measures of disease activity in RA, may help monitor treatment efficacy and improve patient prognosis.

Indexed as

inflammatory markerspan-immune-inflammation value (PIV)rheumatoid arthritis disease activitysystemic immune-inflammation index (SII)systemic inflammation response index (SIRI)

Identifiers

PMID39866302
PMCPMC11758101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.