ArticleJournal of vascular anomalies2024
Once a day administration of R(+) propranolol is sufficient to block vasculogenesis in a xenograft model of infantile hemangioma.
Article in Journal of vascular anomalies, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- R-(+)-propranolol for infantile hemangioma:Frontiers in medicine · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
objectivesInfantile hemangioma (IH) is a benign vascular tumor that occurs in 5% of infants, predominantly in female and preterm neonates. Propranolol is the mainstay of treatment for IH. Given the short half-life of propranolol regarding β-adrenergic receptor inhibition as well as its side effects, propranolol is administered to infants 2-3 times daily with 1 mg/kg/dose. We previously demonstrated propranolol inhibits IH vessel formation via an effect of its R(+) enantiomer on the endothelial-specific transcription factor SRY box 18 (SOX18). In light of this, we hypothesized that R(+) propranolol inhibition of SOX18 is long-lived compared to the beta-blocker effects, and therefore administration of R(+) propranolol once a day would be sufficient to block IH vessel formation.
methodsWe tested the effect of one dose versus two doses of R(+) propranolol in a xenograft model of IH wherein patient-derived hemangioma stem cells (HemSC) were implanted subcutaneously into nude mice. Mice were treated for 7 days with 2 × 12.5 mg/kg/day (n=12) versus 1 × 25 mg/kg/day (n=14) as well as PBS (vehicle control) (n=16) via intraperitoneal injections. The doses were estimated to correlate with those given to infants with IH.
resultsTreatment with R(+) propranolol significantly inhibited vasculogenesis in our IH xenograft model at both 2 × 12.5 mg/kg/day and 1 × 25 mg/kg/day, compared to vehicle controls. No significant difference was observed between the two treatment regimens.
conclusionsOur results suggest implications for the clinical management of infants with IH: Administration of R(+) propranolol can possibly minimize or omit concerning β-adrenergic side effects while only requiring one dose per day.
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