Evidence map›Paper›PMID 39866114›Full record

ArticleStroke2025

Marco Foddis, Sonja Blumenau, Susanne Mueller, Clemens Messerschmidt, Clarissa Rocca, Alistair T Pagnamenta, Katarzyna Winek, Matthias Endres, Andreas Meisel, Arianna Tucci and 5 more

Abstract read
In one paragraph

Article in Stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marco FoddisDepartment of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (M.F., S.B., S.M., K.W., M.E., A.M., U.D., C.S.).ORCID 0000-0003-3354-6790
Sonja BlumenauDepartment of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (M.F., S.B., S.M., K.W., M.E., A.M., U.D., C.S.).ORCID 0000-0002-6606-3800
Susanne MuellerDepartment of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (M.F., S.B., S.M., K.W., M.E., A.M., U.D., C.S.).ORCID 0000-0002-5053-2211
Clemens MesserschmidtBerlin Institute of Health, BIH, Core Unit Bioinformatics, Germany (C.M., D.B.).ORCID 0000-0001-8632-656X
Clarissa RoccaDepartment of Neuromuscular Disease, Queen Square Institute of Neurology, University College London, United Kingdom (C.R.).ORCID 0000-0003-3233-5529
Alistair T PagnamentaWellcome Centre for Human Genetics, Oxford University, United Kingdom (A.T.P.).
Katarzyna WinekDepartment of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (M.F., S.B., S.M., K.W., M.E., A.M., U.D., C.S.).ORCID 0000-0003-3085-9054
Matthias EndresDepartment of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (M.F., S.B., S.M., K.W., M.E., A.M., U.D., C.S.).ORCID 0000-0001-6520-3720
Andreas MeiselDepartment of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (M.F., S.B., S.M., K.W., M.E., A.M., U.D., C.S.).ORCID 0000-0001-7233-5342
Arianna TucciWilliam Harvey Research Institute, Queen Mary University of London, United Kingdom (A.T.).ORCID 0000-0001-5644-0070
Jose BrasDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI (J.B., R.G.).
Rita GuerreiroDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI (J.B., R.G.).ORCID 0000-0001-5879-3486
Dieter BeuleBerlin Institute of Health, BIH, Core Unit Bioinformatics, Germany (C.M., D.B.).ORCID 0000-0002-3284-0632
Ulrich DirnaglDepartment of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (M.F., S.B., S.M., K.W., M.E., A.M., U.D., C.S.).ORCID 0000-0003-0755-6119
Celeste SassiDepartment of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany (M.F., S.B., S.M., K.W., M.E., A.M., U.D., C.S.).ORCID 0000-0002-2837-1765

Funding

Medical Research Council MR/S006753/1Wellcome Trust
6 · The paper itself

Abstract

backgroundContrary to the common belief, the most commonly used laboratory C57BL/6J mouse inbred strain presents a distinctive genetic and phenotypic variability, and for several traits, the genotype-phenotype link remains still unknown. Recently, we characterized the most important stroke survival factor such as brain collateral plasticity in 2 brain ischemia C57BL/6J mouse models (bilateral common carotid artery stenosis and middle cerebral artery occlusion) and observed a Mendelian-like fashion of inheritance of the posterior communicating artery (PcomA) patency. Interestingly, a copy number variant (CNV) spanning

methodsWe applied a combination of techniques (T2-weighted magnetic resonance imaging, time-of-flight angiography, cerebral blood flow imaging, and histology) to characterize the collaterome in 77 C57BL/6J bilateral common carotid artery stenosis, middle cerebral artery occlusion, naive, and sham mice and performed on these Taqman genotyping, exome sequencing, and RNA sequencing. We then investigated the hypothesis that

resultsWe detected an

conclusions

Indexed as

DNA Copy Number VariationsStrokeAgedAnimalsCarotid StenosisDisease Models, AnimalFemaleHumansInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLMiddle AgedSeverity of Illness Indexcarotid stenosisgeneticsmicephenotypestroke

Identifiers

PMID39866114
PMCPMC7617642

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.