Evidence map›Paper›PMID 39865919›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

Hybrid Plasmonic Symmetry-Protected Bound state in the Continuum Entering the Zeptomolar Biodetection Range.

Elena Clabassi, Gianluca Balestra, Giulia Siciliano, Laura Polimeno, Iolena Tarantini, Elisabetta Primiceri, David Maria Tobaldi, Massimo Cuscunà, Fabio Quaranta, Adriana Passaseo and 6 more

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Elena ClabassiCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
Gianluca BalestraCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
Giulia SicilianoCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
Laura PolimenoCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
Iolena TarantiniDepartment of experimental medicine, University of Salento, Lecce, 73100, Italy.
Elisabetta PrimiceriCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
David Maria TobaldiCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
Massimo CuscunàCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
Fabio QuarantaCNR IMM Institute for Microelectronics and Microsystems, Via Monteroni, 73100, Lecce, Italy.
Adriana PassaseoCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
Alberto RainerCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
Silvia RomanoCNR ISASI Institute of Applied Sciences and Intelligent Systems, Naples, 80078, Italy.
Gianluigi ZitoCNR ISASI Institute of Applied Sciences and Intelligent Systems, Naples, 80078, Italy.
Giuseppe GigliCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
Vittorianna TascoCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.
Marco EspositoCNR NANOTEC Institute of Nanotechnology, Via Monteroni, 73100, Lecce, Italy.ORCID https://orcid.org/0000-0001-8170-6694

Funding

Italian Ministry of Research (MUR) in the framework of the National Recovery and Resilience Plan (NRRP), "NFFA-DI" Grant , "I-PHOQS" Grant and under the complementary actions to the NRRP, "Fit4MedRob" Grant , "ANTHEM" Grant , funded by NextGenerationEU B53C22001750006","CUPItalian Ministry of Research (MUR) in the framework of the National Recovery and Resilience Plan (NRRP), "NFFA-DI" Grant , "I-PHOQS" Grant and under the complementary actions to the NRRP, "Fit4MedRob" Grant , "ANTHEM" Grant , funded by NextGenerationEU B53C22004310006","CUPItalian Ministry of Research (MUR) in the framework of the National Recovery and Resilience Plan (NRRP), "NFFA-DI" Grant , "I-PHOQS" Grant and under the complementary actions to the NRRP, "Fit4MedRob" Grant , "ANTHEM" Grant , funded by NextGenerationEU B53C22004310006","CUPB53C22001750006","CUPB53C22006960001","CUPB53C22006710001".Italian Ministry of Research (MUR) in the framework of the National Recovery and Resilience Plan (NRRP), "NFFA-DI" Grant , "I-PHOQS" Grant and under the complementary actions to the NRRP, "Fit4MedRob" Grant , "ANTHEM" Grant , funded by NextGenerationEU B53C22006710001".Italian Ministry of Research (MUR) in the framework of the National Recovery and Resilience Plan (NRRP), "NFFA-DI" Grant , "I-PHOQS" Grant and under the complementary actions to the NRRP, "Fit4MedRob" Grant , "ANTHEM" Grant , funded by NextGenerationEU B53C22006960001","CUPItalian Ministry of Research (MUR) in the framework of the National Recovery and Resilience Plan (NRRP), "NFFA-DI" Grant , "I-PHOQS" Grant and under the complementary actions to the NRRP, "Fit4MedRob" Grant , "ANTHEM" Grant , funded by NextGenerationEU "CUPNational project "Developing National And Regional Infrastructural Nodes Of Dariah In Italy - DARIAH" CIR01_00022.National Recovery and Resilience Plan (NRRP), Mission 4, Component 2, Investment 1.1, Call for tender No. 1409 published on 14.9.2022 by the Italian Ministry of University and Research (MUR), funded by the European Union - NextGenerationEU- Project Title Chiral Bound States IN the Continuum by Shallow 3D Plasmonic SPIRal MEtacrystal (INSPIRE) - Grant Assignment Decree No. 1380 adopted on 01/09/2023 by the Italian Ministry of Ministry of University and Research (MUR) B53D23024270001.National Recovery and Resilience Plan (NRRP), Mission 4, Component 2, Investment 1.1, Call for tender No. 1409 published on 14.9.2022 by the Italian Ministry of University and Research (MUR), funded by the European Union - NextGenerationEU- Project Title Chiral Bound States IN the Continuum by Shallow 3D Plasmonic SPIRal MEtacrystal (INSPIRE) - Grant Assignment Decree No. 1380 adopted on 01/09/2023 by the Italian Ministry of Ministry of University and Research (MUR) CUPTecnopolo per la medicina di precisione" (TecnoMed Puglia) - Regione Puglia: DGR no. 2117 del 21/11/2018 B84I18000540002.Tecnopolo per la medicina di precisione" (TecnoMed Puglia) - Regione Puglia: DGR no. 2117 del 21/11/2018 CUP
6 · The paper itself

Abstract

Photonics bound states in the continuum (BICs) are peculiar localized states in the continuum of free-space waves, unaffected by far-field radiation loss. Although plasmonic nano-antennas squeeze the optical field to nanoscale volumes, engineering the emergence of quasi-BICs with plasmonic hotspots remains challenging. Here, the origin of symmetry-protected (SP) quasi-BICs in a 2D system of silver-filled dimers, quasi-embedded in a high-index dielectric waveguide, is investigated through the strong coupling between photonic and plasmonic modes. By tailoring the hybridizing plasmonic/photonic fractions, a trade-off is selected at which the quasi-BIC exhibits both high intrinsic Q-factor and strong near-field enhancement because of dimer-gap hotspot activation. Not only radiation loss is damped but in a configuration sustaining a lattice of plasmonic hotspots. This leads to an advantageous small modal volume for enhancing light-matter interaction. The layout of nearly embedded dimers is designed to maximize the spatial overlap between the optical field and the target molecules, enhancing reactive sensing efficiency. The architecture is evaluated for its ability to detect transactive response DNA-binding protein 43. The refractometric sensitivity outperforms current label-free biosensing platforms, reaching the zeptomolar range. The approach highlights the potential of combining plasmonic and dielectric nanomaterials for advanced sensing technologies.

Indexed as

bound states in the continuumhybrid metasurfaceshybrid SP‐BICslocalized surface plasmon resonanceszeptomolar biosensing

Identifiers

PMID39865919
PMCPMC11899489

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.