Evidence map›Paper›PMID 39865862›Full record

ReviewAnnals of medicine2025

Effect of cold atmospheric plasma on common oral pathogenic microorganisms: a narrative review.

Jiajun Xin, Hao Zhang, Yushen Li, Yifei Dai, Xiantao Chen, Jiatong Zou, Rui Wang, Zhihui Liu, Bowei Wang

Abstract readReview
In one paragraph

Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiajun XinDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, People's Republic of China.
Hao ZhangDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, People's Republic of China.
Yushen LiDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, People's Republic of China.
Yifei DaiDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, People's Republic of China.
Xiantao ChenDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, People's Republic of China.
Jiatong ZouDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, People's Republic of China.
Rui WangDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, People's Republic of China.
Zhihui LiuDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, People's Republic of China.ORCID 0000-0001-8650-9104
Bowei WangDepartment of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe oral microbiota is a diverse and complex community that maintains a delicate balance. When this balance is disturbed, it can lead to acute and chronic infectious diseases such as dental caries and periodontitis, significantly affecting people's quality of life. Developing a new antimicrobial strategy to deal with the increasing microbial variability and resistance is important. Cold atmospheric plasma (CAP), as the fourth state of matter, has gradually become a hot topic in the field of biomedicine due to its good antibacterial, anti-inflammatory, and anti-tumor capabilities. It is expected to become a major asset in the regulation of oral microbiota.

methodsWe conducted a search in PubMed, Medline, and Wiley databases, focusing on studies related to CAP and oral pathogenic microorganisms. We explored the biological effects of CAP and summarized the antimicrobial mechanisms behind it.

resultsNumerous articles have shown that CAP has a potent antimicrobial effect against common oral pathogens, including bacteria, fungi, and viruses, primarily due to the synergy of various factors, especially reactive oxygen and nitrogen species.

conclusionsCAP is effective against various oral pathogenic microorganisms, and it is anticipated to offer a new approach to treating oral infectious diseases. The future objective is to precisely adjust the parameters of CAP to ensure safety and efficacy, and subsequently develop a comprehensive CAP treatment protocol. Achieving this objective is crucial for the clinical application of CAP, and further research is necessary.

Indexed as

Anti-Infective AgentsMicrobiotaMouthPlasma GasesBacteriaDental CariesHumansPeriodontitisAnti-Infective AgentsPlasma GasesantimicrobialCold atmospheric plasmaoral infectious diseaseoral microorganismsreactive oxygen and nitrogen species

Identifiers

PMID39865862
PMCPMC11774187

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.