Trial reportCurrent pharmaceutical design2025
The Efficacy of Oral Atorvastatin for Skin Toxicity in Breast Cancer Patients Undergoing Radiotherapy: A Randomized, Double-blind, Placebo-controlled Trial.
Trial report in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMost Breast Cancer (BC) patients undergoing Radiotherapy (RT) are potentially susceptible to skin toxicity and prone to clinical symptom complaints. This study aimed to investigate the effect of oral Atorvastatin (ATV) administration on skin toxicity in BC patients undergoing RT.
methodsOne hundred BC patients were randomly assigned to oral ATV (40 mg) or placebo tablets two days before beginning the RT until the eighth week of the RT regimen was completed. Radiation-induced dermatitis was classified according to the Radiation Therapy Oncology Group (RTOG) criteria for eight weeks of treatment. In addition, during the eight weeks of RT, the clinical symptoms, such as pain, itching, burning, and sensitivity, were scored by patients in both groups according to the Visual Analogue Scale (VAS).
resultsNinety-four BC patients were analyzed in this study. At the end of the seventh week of RT, the between- group analysis showed a statistically significant reduction of 20.7% in the ATV group (1.693 ± 0.846) compared to the placebo group (1.900 ± 0.986, P = 0.036). However, the comparison of the dermatitis grade in the ATV and placebo groups showed a reduction of 54.5% in the ATV group; this difference was not statistically significant (P = 0.072). The results of VAS regarding the clinical symptoms of patients showed pain, itching, burning, and sensitivity to touch to be clinically decreased in the ATV group compared to the placebo group in the 8 weeks, but these differences were not statistically significant.
conclusionAccording to the results of this clinical study, the oral administration of ATV at a dose of 40 mg during RT regimens can effectively reduce skin RT-induced toxicity and improve the self-report clinical symptoms among BC patients. CLINICAL TRIAL REGISTRATION NUMBER: IRCT20181005041239N1.
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