ReviewRecent advances in drug delivery and formulation2025
Harnessing Polyphenols and Novel Delivery Strategies for Effective Treatment of Breast Cancer.
Review in Recent advances in drug delivery and formulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
Breast cancer continues to pose a significant global health challenge, with conventional therapies frequently hindered by resistance mechanisms and undesirable side effects. This review investigates the therapeutic potential of polyphenols-naturally occurring compounds recognized for their antioxidant, anti-inflammatory, and anti-cancer properties-as alternative or complementary treatments for breast cancer. We examine the molecular pathways through which polyphenols exert their effects, including their influence on oxidative stress modulation, inflammatory responses, cellular proliferation, apoptosis, and estrogen receptor signalling. Additionally, this review addresses innovative nano-based drug delivery systems such as nanoparticles, liposomes, niosomes, and phytosomes that enhance the stability, bioavailability, and targeted delivery of polyphenols. These advanced formulations aim to overcome challenges related to polyphenol degradation, low solubility, and rapid systemic clearance, thereby enhancing their therapeutic efficacy. Through a detailed analysis, we assess the contributions of various nanocarriers in optimizing the delivery of polyphenols specifically to breast cancer cells while minimizing systemic toxicity. The evidence presented highlights the potential of polyphenols in breast cancer management, further supported by nanoformulations that improve both stability and delivery efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.