Evidence map›Paper›PMID 39865804›Full record

ArticleCurrent cancer drug targets2026

CDK8 as a Therapeutic Target for Overall Survival Prediction in Cervical Squamous Cell Carcinoma (CESC).

Feiting Xie, Qiugang Zhu, Shizhou Yang, Xiaofen Jin, Danqi Ruan, Lingfang Wang, Yang Li, Fang Ren, Xiaojing Chen

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Article in Current cancer drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Feiting XieZhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, China.ORCID 0009-0004-9654-3794
Qiugang ZhuDepartment of Laboratory Medicine, Shangyu People's Hospital of Shaoxing, Shaoxing, China.
Shizhou YangZhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, China.
Xiaofen JinZhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, China.
Danqi RuanDepartment of Laboratory Medicine, Shangyu People's Hospital of Shaoxing, Shaoxing, China.
Lingfang WangZhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, China.
Yang LiZhejiang Key Laboratory of Maternal and Infant Health, Women's Hospital, Zhejiang University School of Medicine, China.
Fang RenDepartment of Gynecology, First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Zhengzhou, Henan, China.
Xiaojing ChenZhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCyclin-Dependent Kinase 8 (CDK8) is a paracrine transcriptional regulator involved in regulating cellular stress response, growth, and neurological functions in conjunction with mediator complex subunits 12 (MED12), MED13, and cyclin C.

objectiveStudying the relationship between CDK8 and cervical squamous cell carcinoma (CESC) has significant clinical implications in diagnosis, treatment, and prognosis. Therefore, we analyzed the relationship between CDK8 and poor prognosis of CESC.

methodsDifferentially expressed genes and their functional enrichment were analyzed using limma R software package. Immune cell infiltration was measured by TIMER and "GSVA" R packaging.

resultsThe results indicated that CDK8 was overexpressed in CESC, and the survival rate of patients in the CDK8 hypermethylation group was higher than that in the CDK8 hypomethylation group. In addition, CDK8 was associated with immune cell infiltration in tumor tissues.

conclusionOverall, these findings provide more evidence for the relationship between CDK8 and a patients overall survival, which could provide insights into clinical diagnosis and prognosis prediction for CESC.

Indexed as

Biomarkers, TumorCarcinoma, Squamous CellCyclin-Dependent Kinase 8Uterine Cervical NeoplasmsDNA MethylationFemaleGene Expression Regulation, NeoplasticHumansPrognosisSurvival RateBiomarkers, TumorCDK8 protein, humanCyclin-Dependent Kinase 8CDK8CESCdiagnosisimmune cell infiltrationmethylationprognosis

Identifiers

PMID39865804

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