SynthesisCancer control : journal of the Moffitt Cancer Center
Effectiveness of Adjuvant Chemo- and Radiotherapy in Thymic Carcinoma Stage II: A Systematic Review and Meta-Analysis.
Synthesis in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- B2 Thymoma with Intracardiac Extension Presenting as Superior Vena Cava Syndrome: Case Report and Literature Review.Acta medica academica · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThymic carcinoma is a rare tumor arising from the epithelial thymic tissue, yet among mediastinal tumors, it is the most common malignant entity. Thymic carcinoma often causes no symptoms and is incidentally discovered. Adjuvant radiotherapy is recommended, particularly in cases of incomplete resection and for stages III and IV, based on current guidelines and existing literature. In stage II (Masaoka-Koga system), the role of chemotherapy remains controversial, particularly in cases of incomplete resection. Therefore, this study aims to assess the effectiveness of adjuvant chemotherapy compared to adjuvant radiotherapy in the treatment of stage II (Masaoka-Koga system) thymic carcinoma after surgery.
methodsA comprehensive literature search was conducted in the Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and MEDLINE/PubMed databases for relevant studies published through April 30
resultsThe review identified a total of 101 studies in the Embase, Cochrane Library, and MEDLINE/PubMed databases. Of these, only eight retrospective studies met the inclusion criteria and were included in the meta-analysis. These eight studies encompassed a total of 323 patients with stage II (Masaoka-Koga system) thymic carcinoma, with an average patient age of 53.8 ± 5.0 years. There was no significant difference in the number of R0 resections between patients receiving adjuvant chemotherapy and those receiving adjuvant radiotherapy (
conclusionsAlthough the results were not statistically significant, the findings suggest that adjuvant chemotherapy might be associated with a more favorable outcome for patients with stage II (Masaoka-Koga system) thymic carcinoma compared to adjuvant radiotherapy.
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