Evidence map›Paper›PMID 39865444›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025

Lipopolysaccharide Causes Acquired CFTR Dysfunction in Murine Nasal Airways.

Jessica W Grayson, T Graham Norwood, Shaoyan Zhang, Daniel Skinner, Do-Yeon Cho, Bradford A Woodworth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jessica W GraysonDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
T Graham NorwoodDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Shaoyan ZhangDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Daniel SkinnerDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Do-Yeon ChoDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.
Bradford A WoodworthDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0003-3292-9167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCystic fibrosis (CF) is a clinical entity defined by aberrant chloride (Cl STUDY

designBasic science.

settingLaboratory.

methodsCFTR

resultsTransepithelial Cl

conclusionTwice daily irrigation with LPS in murine nasal airways over 1 week led to acquired defects in transepithelial Cl

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorLipopolysaccharidesNasal MucosaAnimalsChloridesDisease Models, AnimalMiceMucociliary ClearanceChloridesCystic Fibrosis Transmembrane Conductance RegulatorLipopolysaccharidesCFTRchronic rhinosinusitischronic sinusitishistopathologylipopolysaccharidenasal potential differencesinusitistransepithelial ion transport

Identifiers

PMID39865444
PMCPMC12035511

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.