Evidence map›Paper›PMID 39865396›Full record

ArticleEnvironmental microbiology2025

Regulation of Rhizobial Nodulation Genes by Flavonoid-Independent NodD Supports Nitrogen-Fixing Symbioses With Legumes.

Timothy L Haskett, Louise Cooke, Patrick Green, Philip S Poole

Abstract read
In one paragraph

Article in Environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026
    Review
  2. Review
  3. Microbial drivers of root plasticity.The New phytologist · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Timothy L HaskettDepartment of Biology, University of Oxford, Oxford, UK.
Louise CookeDepartment of Biology, University of Oxford, Oxford, UK.
Patrick GreenDepartment of Biology, University of Oxford, Oxford, UK.
Philip S PooleDepartment of Biology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0001-5087-6455

Funding

Biotechnology and Biological Sciences Research Council BB/T006722/1Royal Commission for the Exhibition of 1851 RF-2019-100238
6 · The paper itself

Abstract

Rhizobia and legumes form a symbiotic relationship resulting in the formation of root structures known as nodules, where bacteria fix nitrogen. Legumes release flavonoids that are detected by the rhizobial nodulation (Nod) protein NodD, initiating the transcriptional activation of nod genes and subsequent synthesis of Nod Factors (NFs). NFs then induce various legume responses essential for this symbiosis. Although evidence suggests differential regulation of nodD expression and NF biosynthesis during symbiosis, the necessity of this regulation for the formation of nitrogen-fixing nodules remains uncertain. Here, we demonstrate that deletion of the Rlv3841 NodD regulatory domain results in a constitutively active protein (NodD

Indexed as

Bacterial ProteinsFabaceaeFlavonoidsGene Expression Regulation, BacterialMedicago truncatulaNitrogen FixationPisum sativumRhizobiumSymbiosisPlant Root NodulationRoot Nodules, PlantBacterial ProteinsFlavonoidsNodD protein, Bacteriaendomycorrhizal fungiendosymbiontsgene expression/regulationmicrobe:higher organism interactionssoil microbessymbionts

Identifiers

PMID39865396
PMCPMC11771551

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.