Evidence map›Paper›PMID 39865395›Full record

ReviewHIV medicine2025

Point-of-care nucleic acid testing - a step forward in controlling the HIV epidemic: A review.

Suleyman Sarp Pinar, Mark Manak, Shanmugam Saravanan, Nesrina Imami, Catherine Kibirige

Abstract readReview
In one paragraph

Review in HIV medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Burden of syphilis among people living with HIV: a large cross-sectional study from Türkiye.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Suleyman Sarp PinarImperial College School of Medicine, Imperial College London, London, UK.
Mark ManakTuresol Consulting, King of Prussia, Pennsylvania, USA.
Shanmugam SaravananSaveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India.
Nesrina ImamiCentre for Immunology and Vaccinology, Imperial College London, London, UK.
Catherine KibirigeCentre for Immunology and Vaccinology, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-8092-6599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe HIV/AIDS epidemic, with 85.6 million infections and 40.4 million AIDS-related deaths globally, remains a critical public health challenge. Current diagnostic methods, primarily fourth-generation immunoassays, have limitations due to their long window periods, and most viral load assays require centralized testing protocols that result in delays, especially in remote regions. NUCLEIC ACID TESTING: Point-of-care (POC) nucleic acid amplification testing (NAAT) presents a transformative approach by reducing the window period for detection to one week and significantly shortening turnaround times for viral load monitoring. DISCUSSION: This review highlights the clinical utility of POC NAAT for acute HIV infection diagnosis, its role in timely combination antiretroviral therapy adjustments, and its potential to reduce the basic reproduction number (R

conclusionBy improving early detection and facilitating faster clinical decisions, POC NAAT enhances the effectiveness of HIV prevention and treatment programmes, particularly in high-risk and remote communities, and supports the global effort to achieve the ambitious UNAIDS 95-95-95 targets.

Indexed as

EpidemicsHIV InfectionsNucleic Acid Amplification TechniquesPoint-of-Care TestingHumansViral LoaddiagnosticsHIVnucleic acidPCRpoint‐of‐caretreatment monitoring

Identifiers

PMID39865395
PMCPMC11970346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.