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ArticleHead & neck2025

Clinico-Pathological Significance of Tumor Infiltrating Immune Cells in Oral Squamous Cell Carcinoma-Hope or Hype?

Rajkumar K Seenivasagam, Ashok Singh, Vinay N Gowda, Dharma R Poonia, Kinjal S Majumdar, Thaduri Abhinav, Pallvi Kaul, Achyuth Panuganti, Vikramjit S Kailey, Rahul Kumar and 1 more

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Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Rajkumar K SeenivasagamDepartment of Surgical Oncology, PSG Institute of Medical Sciences & Research, Coimbatore, India.
Ashok SinghDepartment of Pathology, All India Institute of Medical Sciences, Rishikesh, India.
Vinay N GowdaDepartment of Pathology, All India Institute of Medical Sciences, Rishikesh, India.
Dharma R PooniaDepartment of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, India.ORCID 0000-0003-0224-5012
Kinjal S MajumdarDepartment of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, India.ORCID 0000-0003-4696-3139
Thaduri AbhinavDepartment of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, India.ORCID 0000-0003-3222-8125
Pallvi KaulDepartment of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, India.
Achyuth PanugantiDepartment of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, India.
Vikramjit S KaileyDepartment of Otolaryngology-Head & Neck Surgery, All India Institute of Medical Sciences, Rishikesh, India.
Rahul KumarDepartment of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, India.
Nilotpal ChowdhuryDepartment of Pathology, All India Institute of Medical Sciences, Rishikesh, India.

Funding

All India Institute of Medical Sciences Rihsikesh AIIMS/IM/RC/163/2020/8Manipal Academy of Higher Education
6 · The paper itself

Abstract

backgroundTo correlate between immunohistochemical expression of tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and natural killer (NK) cells with the AJCC 8th edition TNM staging system and other disease-modifying clinico-pathological variables.

methodsThe representative histology sections of tumor invasive margin (IM) and tumor core (TC) were selected according to the International Immuno-Oncology Biomarker Working Group and were subjected to immunohistochemistry with antibodies for TILs (CD3, CD8, FOXP3), NK Cells (CD57), TAMs (CD68, CD163) and pan-leukocyte marker (CD45). Histo-immuno-density-intensity (HIDI) scoring was calculated as a product of the proportion and intensity of staining. Ordinal-ordinal and continuous-ordinal variables were correlated using Kendall's tau-b (τb), and binary-ordinal variables were correlated using Rank-Biserial (r

resultsA total of 111 patients were included in the study. None of the clinical and pathological parameters showed a strong correlation with any of the immune infiltrates including TNM staging.

conclusionWe hypothesize an independent activity of tumor immunology in the disease prognosis.

trial registrationCTRI/2020/07/026335.

Indexed as

Carcinoma, Squamous CellLymphocytes, Tumor-InfiltratingMouth NeoplasmsSquamous Cell Carcinoma of Head and NeckTumor-Associated MacrophagesAdultAgedAged, 80 and overFemaleHumansImmunohistochemistryKiller Cells, NaturalMaleMiddle AgedNeoplasm StagingPrognosisOral cancersquamous cell carcinomatumor‐associated macrophagestumor‐infiltrating lymphocytestumor microenvironment

Identifiers

PMID39865357
PMCPMC12068536

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