ArticleJournal of orthopaedic surgery and research2025
miR-208a-3p discriminates osteoporosis, predicts fracture, and regulates osteoclast activation through targeting STC1.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- circMYO9B affects the progression of periodontitis by targeting the miR-4731-5p/USP15 axis.Journal of periodontal & implant science · 2026Article
- MiR-642a-3p increases the risk of postmenopausal osteoporosis and fractures by targeting INO80.Hereditas · 2026Article
- From Osteogenesis to Diagnosis: The Role of microRNAs as Biomarkers for Osteoporosis.International journal of molecular sciences · 2026Review
- MiRNA-mRNA network in osteoporotic fractures proposes the functional mechanism of hsa-miR-32-3p/TNFSF11 axis.Journal of orthopaedic surgery and research · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundOsteoporosis (OP) frequently occurs in post-menopausal women, increasing the risk of fracture. Early screening OP could improve the prevention of fractures.This study focused on the significance of miR-208a-3p in diagnosing OP and development regulation, aiming to explore a novel biomarker and therapeutic target for OP.
methodsThe study enrolled a total of 154 post-menopausal women and grouping was performed based on the incidence of OP and fracture. The significance of miR-208a-3p was evaluated from the perspectives of menopausal correlation, OP diagnosis, and fracture prediction. In mechanism, the regulatory effect and mechanism of miR-208a-3p on osteoclast activation was investigated.
resultsmiR-208a-3p was menopause-related showing a negative correlation with E
conclusionSerum miR-208a-3p served as a diagnostic biomarker for OP and a risk factor for fracture in post-menopausal women. miR-208a-3p regulated macrophage inflammation and further mediated osteoclast activation via targeting STC1.
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