ArticleBMC plant biology2025
Genetically and chemically intraspecific variations of Ficus hirta provide novel insights into its protection and utilization.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Bioactive compounds fromBiochemistry and biophysics reports · 2026Review
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5 authors.
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Abstract
backgroundRadix Fici Hirtae, the dry root of Ficus hirta, is a famous ethnomedicine and food that has been widely used by Yao and Zhuang nationalities in southern China for its potent antitumor, antifungal, and hepatoprotective effects. Recently, owing to over-exploitation and habitat destruction, F. hirta has been pushed to the brink of depletion. In addition, cultivation and breeding have resulted in severe intermixing and degeneration over the past 20 years. However, little is known about the genetic background and medicinal quality of F. hirta across populations, which restricts its protection and utilization. In this study, we conducted an evaluation of the chloroplast DNA (cpDNA) genetic diversity and population structure of F. hirta in southern China, and further evaluated its medicinal quality based on HPLC fingerprinting and the content determination of the active components.
resultsF. hirta presented high overall genetic diversity (Hd = 0.792) for cpDNA but low genetic diversity (Hd = 0.000 ~ 0.467) within populations. All seventeen populations were genetically assigned into two groups, most of which were not geographically clustered together. Mantel test revealed no significant isolation by distance pattern for F. hirta (P = 0.233), which might be related to its habitat fragmentation. High population differentiation (F
conclusionsF. hirta presented high overall genetic diversity and population differentiation, but without significant isolation by distance, which might relate to its habitat fragmentation. Different geographic origins' Radix Fici Hirtae were chemically clustered into three groups, which were mainly differentiated by psoralen and bergapten. The medicinal quality of Radix Fici Hirtae exhibited a southwest to southeast variation pattern across southern China, and its quality formation was influenced mostly by geographical environments. Our results provide references for the conservation, core collection construction and improvement of F. hirta.
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