ArticleBMC microbiology2025
Imbalance of oral microbiome homeostasis: the relationship between microbiota and the occurrence of dental caries.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Modulating Oral Microbiota to Prevent Dental Caries: A Microbial Ecology Approach.Dentistry journal · 2026Review
- Femtosecond laser-induced micro/nanostructures loaded with silver nanoparticles on clear aligners prevent bacterial infection.BMC oral health · 2026Article
- Salivary microbiota composition and caries status in children with hearing impairment: a cross-sectional comparative study.Clinical oral investigations · 2026Article
- Effects of Oral Probiotics onDentistry journal · 2026Review
- Supragingival Biomarker flora of Children With and Without Cariogenic Disease and Black Stains, Aged 3 to 6 Years.International dental journal · 2026Article
- Blueberry leaf polyphenols suppress biofilm formation and restore oral microbial homeostasis for caries control.Journal of oral microbiology · 2026Article
- Review
- Oral microbiome diversity and all-cause mortality in hypertensive adults: findings from a nationally representative cohort.Journal of oral microbiology · 2026Article
- Microbial signatures of dental caries in the incarcerated elderly: a salivary microbiota study in a restricted environment.Journal of oral microbiology · 2026Article
- Relationship between oral microbiota and chronic kidney disease: facts and perspectives.Journal of oral microbiology · 2026Review
- The Oral-Gut Microbiota Axis Across the Lifespan: New Insights on a Forgotten Interaction.Nutrients · 2025Review
- Review
- Oral Health Conditions and Physical Performance in Two Different Professional Team Sports in Germany: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2025Article
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Authors and funding
8 authors.
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Abstract
backgroundStreptococcus mutans is recognized as a key pathogen responsible for the development of dental caries. With the advancement of research on dental caries, the understanding of its pathogenic mechanism has gradually shifted from the theory of a single pathogenic bacterium to the theory of oral microecological imbalance. Acidogenic and aciduric microbial species are also recognized to participate in the initiation and progression of dental caries. This study is designed to elucidate the relationship between oral microbiome dysregulation and the initiation of dental caries.
results16 S rRNA gene sequencing of saliva and dental plaque from the Specific Pathogen Free Control group and the Specific Pathogen Free sucrose diet group revealed that a sucrose diet significantly influenced the composition of the oral microbiome. At the phylum level, the dominant microbial communities in both groups of mice were Firmicutes, Proteobacteria, Unclassified Bacteria, Actinobacteria, and Bacteroidetes. At the genus level, statistical analysis identified significant differences in the abundance of 18 genera between the two groups. The relative abundance of the Gemella genus was significantly increased in the SPF Sucrose group. The SPF Control group and the Germ-free Control group have no differential bacterial genera in the oral microbiome. Micro-CT examination of the mandibles revealed the development of dental caries in both the SPF Sucrose group and the Germ-free Sucrose group.
conclusionsThis study indicates that a dysbiotic microbial community can lead to the development of caries. Lays the foundation for further research into the etiology of dental caries.
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