Evidence map›Paper›PMID 39865180›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

PSMA PET/CT based multimodal deep learning model for accurate prediction of pelvic lymph-node metastases in prostate cancer patients identified as candidates for extended pelvic lymph node dissection by preoperative nomograms.

Qiaoke Ma, Bei Chen, Robert Seifert, Rui Zhou, Ling Xiao, Jinhui Yang, Axel Rominger, Kuangyu Shi, Weikai Li, Yongxiang Tang and 1 more

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Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qiaoke Ma *Department of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
Bei Chen *Department of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
Robert SeifertDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
Rui ZhouSchool of Zhang Jian, Nantong University, Nantong, Jiangsu, P.R. China.
Ling XiaoDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
Jinhui YangDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China.
Axel RomingerDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
Kuangyu ShiDepartment of Nuclear Medicine, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
Weikai LiCollege of Mathematics and Statistics, Chongqing Jiaotong University, Chongqing, P.R. China. leeweikai@cqjtu.edu.cn.
Yongxiang TangDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China. xyyf0401@qq.com.
Shuo HuDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, P.R. China. hushuo2018@163.com.ORCID 0000-0003-0998-8943

Funding

China Postdoctoral Science Foundation 2022M723561clinical research foundation of the National Clinical Research Center for Geriatric Diseases (XIANGYA) 2020LNJJ01Clinical Research Foundation of the National Clinical Research Center for Geriatric Diseases (XIANGYA) 2023LNJJ16Fundamental Research Funds for the Central Universities NJ2022028National Clinical Key Specialty Project Foundation Z2023004National Key Program of China 2022YFC2503804National Natural Science Foundation of China 62306051National Natural Science Foundation of China 62481540175National Natural Science Foundation of China 81801740Natural Science Foundation of Hunan Province 2020JJ5922Natural Science Foundation of Hunan Province 2021JJ31060Science and Technology Innovation Program of Hunan Province 2021RC4056Science Fund for Distinguished Young Scholars of Hunan Province 2024JJ2094the Scientific and the Technological Research Program of Chongqing Municipal Education Commission KJQN202300718
6 · The paper itself

Abstract

purposeTo develop and validate a prostate-specific membrane antigen (PSMA) PET/CT based multimodal deep learning model for predicting pathological lymph node invasion (LNI) in prostate cancer (PCa) patients identified as candidates for extended pelvic lymph node dissection (ePLND) by preoperative nomograms.

methods[

resultsOur multimodal model incorporated clinical information, maximum standardized uptake value (SUV

conclusionOur multimodal deep learning model, which incorporates preoperative PSMA PET/CT imaging, shows enhanced predictive capabilities for LNI in clinically localized PCa compared to PSMA PET/CT visual evaluation result and existing nomograms like the MSKCC and Briganti-2017 nomograms. This model has the potential to reduce unnecessary ePLND procedures while minimizing the risk of missing cases of LNI.

Indexed as

Antigens, SurfaceDeep LearningGlutamate Carboxypeptidase IILymph Node ExcisionNomogramsPositron Emission Tomography Computed TomographyProstatic NeoplasmsAgedHumansLymphatic MetastasisMaleMiddle AgedPelvisPreoperative PeriodAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IIDeep learningLymph node invasionProstate cancerProstate-specific membrane antigen positron emission tomography

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.