Evidence map›Paper›PMID 39865138›Full record

ArticleScientific reports2025

Tailoring and characterization of bioactive graft material for alveolar bone preservation and regeneration in fresh extraction sockets of dog model.

Ayat Hamdy, Manal Saad, Rania ElBackly, Samir Nouh, Himanshu Jain, Mona Marei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayat HamdyTissue Engineering Laboratories, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Manal SaadTissue Engineering Laboratories, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Rania ElBacklyTissue Engineering Laboratories, Faculty of Dentistry, Alexandria University, Alexandria, Egypt. rania.elbackly@alexu.edu.eg.
Samir NouhTissue Engineering Laboratories, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Himanshu JainInstitute for Functional Materials and Devices (I-FMD), P.C. Rossin College of Engineering and Applied Science, Lehigh University, Bethlehem, PA, USA.
Mona MareiTissue Engineering Laboratories, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to tailor an osteoinductive scaffold for alveolar bone regeneration and around immediately placed implants in extraction sockets of dogs. Tailored amorphous multiporous bioactive glass (TAMP -BG) was prepared and characterized for bioactivity and response of human alveolar bone marrow mesenchymal stem cells (hABMSCs). Extraction sockets of twenty-two male mongrel dogs received TAMP-BG in the right side around implant in the distal socket of the mandibular fourth premolar (P4), while the adjacent empty mesial socket of the same tooth was filled with the same graft. Autologous bone chips were used in the left side. Animals were euthanized at 1, 2, 4, 8 &12 weeks for histological and SEM analyses. SEM/EDX, FTIR and XRD analyses displayed formation of a bioactive hydroxycarbonated apatite layer. TAMP-BG significantly increased proliferation and migration of hABMSCs. Histologically, at the 1

Indexed as

Alveolar ProcessBiocompatible MaterialsBone RegenerationTooth SocketAnimalsCell ProliferationDogsHumansMaleMesenchymal Stem CellsTissue ScaffoldsTooth ExtractionBiocompatible MaterialsAlveolar bone defectBioactive glassDegradable biomaterialsDynamic tissue regenerationMulti-porous scaffoldOsseointegration

Identifiers

PMID39865138
PMCPMC11770185

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.